If you did not get a SAN cert that included your netbios name, then yes. You need to run new-exchangecertificate to generate request; upload to your CA server. Download the cert , import the cert, and enable the cert for IMAP.
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We have exchange 2007 in out network. Few days back we have renewed our SSL certificate on Exchange Servers at different sites, those were purchased from Verisign. Everything was working fine, till few users reported problem in connecting to mail server using IMAP, MAC, thunderbird etc. We have checked on the server it is giving error for some internal self signed certificate expiry. Do we need to re-install the self signed certificate for SMTP as users are not able to send emails using the MAC, Thunderbird etc.