[estiv] Invitation abstract submission

From: Witters Hilda <hilda.witters@xxxxxxx>
To: "'estiv@xxxxxxxxxxxxx'" <estiv@xxxxxxxxxxxxx>
Date: Mon, 25 Apr 2011 23:05:55 +0200
31th International Symposium on Halogenated Persistent Organic Pollutants - 
DIOXIN 2011, 21-25 August, Brussels, Belgium
More information: www.dioxin2011.org/<http://www.dioxin2011.org/>
Deadline abstract submission: 01 May 2011
Dear colleagues,
At Dioxin 2011 we will get the opportunity to update the state of the art on 
the science of persistent organic pollutants (POPs), such as dioxins, PCB's and 
many more emerging organohalogen compounds (e.g. brominated and fluorinated 
chemicals) which persist in the environment and pose health risks to wildlife 
and man.
There will be a joint session with the European Society for Toxicology in Vitro 
(ESTIV) on "Alternative tests to evaluate hazards and potency of POPs". We 
invite you to submit an abstract for this session  and contribute to new 
knowledge of these chemicals as obtained with alternative tests. This may 
include mechanistic information and  improved prediction of potential human 
toxicity. Former efforts across the toxicological community to study exposure 
and effects of POPs mainly relied on animal studies. But in view of high need 
for testing of unknown or new chemicals, environmental mixtures, and taking 
into account the EU-animal legislation in favour of 3R (refinement, reduction, 
replacement), a paradigm shift in toxicity testing requiring new approaches 
does evolve. In silico methods, biochemical and cell-based assays, as well as 
methods using lower organisms (e.g. zebrafish, fly,..) are investigated as 
alternative methods. Innovative approaches (-omics), identification of toxicity 
pathways and mechanism-based profiling of POPs can offer new insights into 
hazards of these chemicals, with relevance for human health risk assessment.
On behalf of
Dr. Hilda Witters & Dr. Juliette Legler, Chairs of the session "alternative 
tests" at Dioxin 2011 and
Prof. Dr. Greet Schoeters, President of ESTIV



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[estiv] Invitation abstract submission

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