[Cangen-L) Re: The Regulation of Genomic Imprinting and XInactivation in Mice
- From: Rievaulx Canines <rievaulx@xxxxxxxxxxxxx>
- To: cangen-l@xxxxxxxxxxxxx
- Date: Sat, 20 Jul 2002 01:53:45 -0700
I'm hoping that one of the more qualified individuals on this list will provide
some
more information about the same. I reread Susan's note on it and then through
these,
yes including the BORIS paper, and came to consider that what they state is very
different then what many had considered to be the inheritance pattern of X.
I will send through the paper on methylation when I can sift through all the
posts
that filled my email today.:-)) It seems from reading this paper that I for
one
need to understand that process more and the H19 and Igf2 functions in an
attempt to
comprehend what is being said regarding insulator elements and imprinting.
Most of the papers were sent in pdf form and I will attempt to send it to the
list
complete. The BORIS paper was sent on earlier.
Carolyn
(who now is back to work on her own papers as my brain hurts.:-))
>
> I want to make sure I understand the references above to X inactivation, so
> I hope someone will comment. I had thought that X-linked expression applied
> to only a relative few traits. Am I misreading the paragraph above, or are
> the researchers suggesting that every time an X chromosome is passed on that
> there is some X inactivation process at work to determine which X will be
> inherited in the next generation? Would this mean that which X is inherited
> is no longer thought to be a matter of classic Mendelian inheritance? I
> guess I'm asking if the same X chromosome is always "silenced," or if the
> researchers are only referring to X-linked processes. And, is it possible
> to have X inactivation processes present in the X received from males?
>
> Carlotta Cooper
> eshever@xxxxxxxxxxxxxx
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