[blindza] Fw: Implantable visual prostheses

  • From: "Jacob Kruger" <jacobk@xxxxxxxxxxx>
  • To: "BlindZA" <blindza@xxxxxxxxxxxxx>
  • Date: Sun, 19 Aug 2007 20:25:49 +0200

These are exactly the sort of thing that would be 'good' for me since they would basically bypass the optical nerve etc.


Stay well

Jacob Kruger
Blind Biker
----- Original Message ----- Implantable visual prostheses.

Visual impairment and blindness is primarily caused by optic neuropathies
like injuries and glaucomas, as well as retinopathies like agerelated
macular degeneration (MD), systemic diseases like diabetes, hypertonia
and hereditary retinitis pigmentosa (RP). These pathological conditions
may affect retinal photoreceptors, or retinal pigment epithelium, or
particular subsets of retinal neurons, and in particular retinal ganglion
cells (RGCs). The RGCs which connect the retina with the brain are unique
cells with extremely long axons bridging the distance from the retina to
visual relays within the thalamus and midbrain, being therefore vulnerable
to heterogeneous pathological conditions along this pathway. When becoming
mature, RGCs loose the ability to divide and to regenerate their
accidentally or experimentally injured axons. Consequently, any loss
of RGCs is irreversible and results to loss of visual function. The
advent of micro- and nanotechnology, and the construction of artificial
implants prompted to create visual prostheses which aimed at compensating
for the loss of visual function in particular cases. The purpose of the
present contribution is to review the considerable engineering expertise
that is essential to fabricate current visual prostheses in connection
with their functional features and applicability to the animal and human
eye. In this chapter, 1) Retinal and cortical implants are introduced,
with particular emphasis given to the requirements they have to fulfil
in order to replace very complex functions like vision. 2) Advanced work
on material research is presented both from the technological and from
the biocompatibility aspect as prerequisites of any perspectives for
implantation. 3) Ultimately, experimental studies are presented showing
the shaping of implants, the procedures of testing their biocompatibility
and essential modifications to improve the interfaces between technical
devices and the biological environment. The review ends by pointing to
future perspectives in the rapidly accelerating process of visual
prosthetics and in the increasing hope that restoration of the visual
system becomes reality.

By S. Thanos, P. Heiduschka and T. Stupp;
Acta Neurochir Suppl. 2007; 97(Pt 2): 465-72.

Source URL:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed&cmd=retrieve&dopt=AbstractPlus&list_uids=17691336


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