Dear all We have no speaker for this week's journal club, so as an alternative the COMBIO seminar, 9-10am at IMB looks like it has a couple of interesting talks lined up. More details copied below. See you there Gib ----------------------------- Hi everyone, Please join us for COMBIO on March 15th at 9AM. As usual, we will have two presentations in the QBP Level 3 Large Seminar Room. You can follow the seminar series here: https://sites.google.com/site/imbcombio/ If you wish to receive further notices of COMBIO Subscribe by sending an email to 'combio-subscribe@xxxxxxxxxxxxx<mailto:combio-subscribe@xxxxxxxxxxxxx>' There is a possibility of morning tea this week... -- Craig Primmer - University of Turku, Academy Professor (guest researcher at IMB) Ecological and evolutionary 'omics: a couple of examples and their bioinformatic challenges Sarah Song, Biostatistician - Queensland Centre for Medical Genomics and UQ Centre for Clinical Research qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles In this talk I will describe a statistical model to estimate tumour cellularity from Single-Nucleotide Polymorphism array profiles of paired tumour and normal samples. qpure is a software implementation of the method. The advantage of using the qpure method is that it is an unbiased statistical approach that directly measures tumor content from the DNA sample that will be used in downstream molecular studies. Our studies show that there is a medium correlation 0.42 (p-value = 0.0001) between tumor cellularity estimated by qpure and histological review. And there is a high correlation 0.87 (p-value < 2.2e-16) between cellularity estimates by qpure and deep Ion Torrent sequencing of known somatic variants; and a weaker correlation 0.32 (p-value = 0.004) between IonTorrent sequencing and histological review. This suggests that qpure is an effective tool to estimate tumour cellularity and will assist in interpreting the biology of that particular cancer. -- Lynn Fink, Ph.D. Deputy Bioinformatics Manager Queensland Centre for Medical Genomics Institute for Molecular Bioscience The University of Queensland St Lucia QLD 4072 Australia +61-7-3346-2198