[ SHOWGSD-L ] Re: von Wilderbrands disease
- From: RihadinK9@xxxxxxx
- To: showgsd-l@xxxxxxxxxxxxx
- Date: Fri, 14 Jan 2005 11:23:01 EST
In a message dated 1/14/2005 10:46:09 AM Eastern Standard Time,
wynsum@xxxxxxxxxxxxx writes:
--> There has been a test for VwD since the seventies. It shows an index.
OVERT CARRIER and CLEAR.
Because it is an index and not a DNA test, you got a range.
Yes, that was/is the blood test for Vwd. That is the same test once used
for Shelties as well. It is a different test than the now available DNA test.
Vetgen now has a DNA test for Vwd in Dobes (and several other breeds,
including Shelties). With the DNA test you get definitive results - Clear,
Carrier
and Affected. Period.
As of Jan 2004 those Dobes tested by DNA showed 25% clear, 49% carrier and
26% Affected. The report unfortunately doesn't say how many have been tested.
But given those numbers it would not be wise to throw out all carriers. You
would have no breed left.
Pembrokes also have now a DNA test for Vwd.
Hemophilia (A&B) is a different bleeding disease from Vwd. Both Hemophilia A
& B are sex linked, affecting males and carried by females. Vwd is not sex
linked and can affect both male and female. Hemophilia A is the lack of
factor VIII, Hemophilia B is the lack of Factor IX and Von Willebrand's
disease
(VWD) is caused by a deficiency in the amount of a protein needed to help
platelets (a blood cell used in clotting) seal broken blood vessels. The
deficient protein is called von Willebrand factor antigen.
There are three types of von Willebrand's disease. In Type I von Willebrand's
disease, all the proteins making up von Willebrand's factor are present but
they are present in very low amounts. This is the type common in the Doberman
pinscher, the Sheltland sheepdog, the German Shepherd dog, and the Standard
Poodle. In Type II von Willebrand's disease, the larger proteins making up
von Willebrand's factor are completely absent. This creates more severe
bleeding episodes and represents the type of von Willebrand's disease usually
seen
in German short-haired and wire-haired pointers. In Type III von Willebrand's
disease, there is simply no von Willebrand's factor at all. This is the most
severe form and is usually seen in Scottish terriers, Chesapeake Bay
retrievers, and Sheltland sheepdogs. Von Willebrand's disease is not limited
to the
breeds listed here; forms of von Willebrand's disease have been found in over
50 breeds and in cats and humans as well.
Unlike the genetics of Hemophilia A in humans, which is reviewed in detail in
virtually every high schoole biology class as a sex linked recessive trait,
von Willebrand's disease is not as simple. Males and females are equally
affected and the inheritance seems to be recessive but complicated.
I am not a Vet of course, but I have MUCH experience with Vwd. I had
Shelties that were affected with it. Due to that I have studied a LOT. We
celebrated when a DNA test was finally developed for Shelties.
Ginger Cleary, Dallas, GA_ http://www.rihadin.com _
(http://www.rihadin.com/) _http://groups.yahoo.com/group/pet-law/_
(http://groups.yahoo.com/group/pet-law/) Just because you do not take an
interest in politics doesn't mean
politics won't take an interest in you. -Pericles (430 B.C.)
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