I don't even know what MDR1 is, imagine that! Carol ----- Original Message ----- From: "Ginger Cleary" <cleary1414@xxxxxxxxxxx> To: "Showgsd-L@Freelists. Org" <showgsd-l@xxxxxxxxxxxxx> Sent: Monday, January 29, 2007 10:57 AM Subject: [ SHOWGSD-L ] ivermectin transmission to herding dogs Ginger Cleary - Rome, GA www.rihadin.com "Laws against something 'that other guy' does will eventually get US because we are all someone's 'other guy.' " Walt Hutchens,2007 -----Original Message----- OT-Livestock & dogs - Ivermectin risk For those that have Aussies or BC's. A mutation of the MDR1 was just found in BC's so this situation with livestock could be of great importance. I suppose its just a matter of time before more breeds fall susceptible. more info on the MDR1 gene ( & how they are finding its far more complex than just Ivermectin) can be found at http://www.vetinfo4dogs.com/ Permission to forward or reprint granted. I was recently contacted by someone asking whether a dog could have an MDR1 reaction due to eating feces from Ivermectin-treated livestock. I wasn't sure about that, so I checked with Dr. Katrina Mealy at Washington State University. Dr. Mealy is the scientist who discovered the MDR1 gene. She told me that Ivermectin and the related drug, selamectin, were shed in feces of treated animals in active form. She went on to say that .they have had a number of reports on dogs that had ingested enough feces to have serious to fatal MDR1 reactions. If you have Aussies or dogs of any other MDR1 breed who are prone to poop eating and may have access to excrement from livestock, it would be wise to do whatever you can to prevent them from doing so. If you do not know the MDR1 status of your Aussies, I *strongly* recommend that you get them screened. Fully a third of Aussies have at least one copy of the mutation. Test kits are available from WSU: http://www.vetmed.wsu.edu/depts-VCPL/ Even one copy may cause some level of reaction with some drugs. Ivermectin and similar drugs are not the only ones that can cause reactions. For an extensive list of MDR1 reactive drugs, including alternate brand names, see: http://www.busteralert.org/ CA ________________________________ C.A. Sharp Pres. Australian Shepherd Health & Genetics Institute, Inc. All Aussies All Genes All the Time http://www.ashgi.org Editor, Double Helix Network News ============================================================================ POST is Copyrighted 2006. All material remains the property of the original author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind are permitted without prior permission of the original author AND of the Showgsd-l Management. ALL RIGHTS RESERVED. ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE PROSECUTED. For assistance, please contact the List Management at admin@xxxxxxxxxxxx VISIT OUR WEBSITE - www.showgsd.org ============================================================================ ============================================================================ POST is Copyrighted 2006. All material remains the property of the original author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind are permitted without prior permission of the original author AND of the Showgsd-l Management. ALL RIGHTS RESERVED. ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE PROSECUTED. For assistance, please contact the List Management at admin@xxxxxxxxxxxx VISIT OUR WEBSITE - www.showgsd.org ============================================================================