HI, this is what I got from my vet after describing the symptoms of these puppies and their mother...Syd -------------------------------------------------------------- The â??toxic milkâ?? diagnosis makes little sense, but putting the litter on antibiotics to cover a possible bacterial problem seems justifiable. It is certainly true that the lochia discharge is going to be full of bacteria and that this is generally not a problem. I have seen puppies consume lochia and consume overtly mastitic milk with no problems whatsoever. So long as the bitch is not overtly ill, it seems unlikely that any of these secretions contain problematic bacteria. Nevertheless, antibiotic prophylaxis is prudent in this case. The most likely source of the problem is the bitchâ??s behavior. She is probably not taking good care of the pups. In this situation it is likely that some of the pups are not being well fed. (Was milk present in the necropsy?) Nervous mothers can vacillate from being too neglectful to overly attentive to vicious toward their babies. Sometimes the puppy is simply smothered out of clumsiness or over-mothering. Detecting this on a gross necropsy can be difficult if the practitioner is not skilled and thorough. Even in this day of CSI, we cannot always recognize the cause of death. I once had a client bring me 4 GSD puppies over 5 days, each of which was found dead mysteriously with everyone else perfectly normal. I dutifully necropsied each pup and because the gross pathology varied from pup to pup, my diagnosis was trauma inflicted by the mother. The client refused to believe the bitch was murdering her babies since she seemed so â??motherlyâ?? until he found only half of one puppy in the whelping area. At that point he removed the remaining puppies and hand raised them successfully. Even if the pups are being well supplemented now, they may not have received adequate colostrum during their first feedings on mom. It is possible to detect this low colostrum situation by checking a blood sample on one or more puppies. It is not necessary to do an actual antibody measurement; one can infer the level is adequate if their total serum protein level is normal. Testing for serum protein is cheap and easily measured in house. If they did not get adequate colostrum, corrective action can be taken. The best one can do with newborn puppies is to make sure they are warm, well fed, and protected from injury. Hopefully the two puppies lost from this group will be the end of the problem. If another dies, a thorough necropsy should be performed with tissue samples taken from every major organ for histology. Examining the tissues at a microscopic level is the best chance of reaching a diagnosis. Keith D. Norton, DVM ____________________________________ In a message dated 5/21/2005 8:39:12 PM Pacific Standard Time, chcohosh@xxxxxxxxxxxx writes: It's me again (and thank you to all who replied on the fear issue - have shared the suggestions and comments with the mother). I have a dilemma that I hope some of you folks may shed some light on. Three days ago I announced the birth of a litter of 12 . I have since lost two - an autopsy today in his office showed normal organs and no sign of any disease. I have been supplementing as the dam does not have much milk and is very nervous about all these pups. Here is the problem - the vet here in VA (small town) says she has "toxic milk syndrome". He cultured vaginal discharge and said it was full of bacteria and puss. I felt that the discharge look normal to my other bitch's postpartum. It was pink tinged and milky white without order. This in turn led him to the toxic milk diagnosis. She was x-rayed after delivery and there was nothing left in the uterus. He gave a shot of penicillin at that time "to ward off any problems". Now he has said to take her off the pup - has given antibiotics for both her and the pups. My vet from PA (who I called for a second opinion) said that he didn't think that an office autopsy could diagnosis many causes of death in a pup and advised to send the pup to a clinic/vet school for definitive workup. He also was not aware of "toxic milk", said all postpartum bitches had bacteria in the discharge and it could not hurt the pups. He didn't feel the antibiotics would hurt and said to go ahead of use them. He advises to put the bitch back with the pups. The bitch does seem nervous and overwhelmed by all the pups and I know this can cause a milk problem. Any one with any words of wisdom out there who has had this problem or knows about it?? Thanks for any help you might have to give. 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