[ SHOWGSD-L ] cancer vaccine
- From: MORGAN LEWIS <shadowland22000@xxxxxxxxx>
- To: germanshepherds4show@xxxxxxxxxxxxxxx, gsdgeneticdefects@xxxxxxxxxxxxxxx, gsd showlist <showgsd-l@xxxxxxxxxxxxx>
- Date: Mon, 9 Jul 2007 07:05:45 -0700 (PDT)
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YAHOO.Shortcuts.overlaySpaceId = "97546169"; YAHOO.Shortcuts.hostSpaceId =
"97546168"; DULUTH, GA. ? The U.S. Department of Agriculture
approved the first
conditional license for a cancer therapeutic vaccine from Merial Ltd.
The vaccine ranks as the world's first for animals or humans,
explains Dr. Bob Menardi, Merial's manager of technical services.
The therapeutic vaccine will make its way to market this month as a
treatment for stage II or stage III oral melanoma in dogs.
Available through boarded oncologists, the conditional license from
USDA represents a milestone, Menardi says. "This vaccine is an
example of how human medicine and veterinary medicine can work
together for the benefit of both species," he adds.The vaccine
represents a decade-long collaboration with researchers at New York's
Animal Medical Center (AMC) and Memorial Sloan-Kettering Cancer
Center.
Robert Nordgren, Merial's vice president for biological research and
technology acquisition, explains that the DNA vaccine alerts the
immune system to the presence of the melanoma tumor protein
tyrosinase. The gene for human tyrosinase protein is inserted into a
DNA plasmid, which in turn stimulates an immune response in the
canine patient suffering from melanoma.
"The earlier you begin immunotherapy the greater the chances for
survival," Nordgren adds.
The vaccine shows promising improvements in survival times when
compared to surgery and radiation. In fact, in a Phase I clinical
trial of dogs with advanced malignant melanoma after DNA vaccination
with xenogeneic human tyrosinase, the median survival time was 389
days for dogs with stages II, III or IV canine melanoma receiving
four biweekly vaccinations. In comparison, the historical median
survival time for dogs with stage II oral melanoma is less than 150
days; for dogs with stage II or stage IV it is less than two to three
months.
Studies demonstrating efficacy and safety were conducted by AMC's
Philip Bergman, DVM, MS, PhD, Dipl. ACVIM. His studies from 2000 to
present have shown an increase in survival times.
Research for a conditional license demonstrates "a reasonable
expectation of safety," Menardi says. Follow-up studies are ongoing
to pursue full licensure and further support safety and efficacy of
the vaccine.
For oncologists using the treatment, the vaccine is administered
using a canine transdermal device. The Canine Melanoma Vaccine is
administered in a 0.4mL dose volume. The injection site for all dogs
is the muscle of the medial thigh just caudal to the femur. Initial
treatment requires four doses of vaccine at two-week intervals. A
booster dose should be administered at six-month intervals, the
company says.
For fastest response, call
(888) MERIAL1
www.merial.com/
---------------------------------
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