[ SHOWGSD-L ] Re: [ SHOWGSD-L ]Toxic Gut/Research Review (long)
- From: Zoa Rockenstein <zrockenstein@xxxxxxxxx>
- To: TISHW@xxxxxxx, fmurch@xxxxxxxxxxxxx, showgsd-l@xxxxxxxxxxxxx
- Date: Mon, 19 Jan 2009 08:35:17 -0800 (PST)
Tish and others,
I was filing a bunch of dog stuff yesterday and found some notes I had made at
the 2007 National on a handout we got from Dr. Mathew Pletcher/Laura Schultz at
the Scripps Research Institute in Jupiter, FL. See contact info below. Their
project is called The Canine Genomics Initiative. My notes say that they
agreed to look for a bloat/torsion gene in their research. What they want from
us is DNA samples. I don't know if they are still willing to do this. Is
anyone working with them? Is the PC supporting that?
While reading the recent list posts, I did a quick search of the veterinary
literature. The 2003 conclusions of Dr. Jerold Bell regarding a hypothesized
genetic component of bloat is that, like dysplasia, it is a polygenic trait.
Among many other things he writes that are worth reading, he says that managing
a polygenic trait requires a knowledge of breadth of pedigree regarding the
trait as well as depth. He says, in fact, that breadth is more important. In
other words we need to know if the siblings of an ancestor were affected by
bloat. This is a more important genetic indicator than the direct ancestor.
Naturally, that kind of information is much harder to come by.
Dr. Larry Glickman at Purdue studied 1,914 dogs with regard to bloat/torsion in
1994. The dogs had no prior history of bloat. Eleven large and giant breeds
were represented. This is the kind of study that appeals to me as an academic,
although I wish it were more recent. Risk factors identified in this study
included: (1) (greatest) chests that are deep and narrow (2) lean dogs (3) old
dogs (4) fearful, nervous, or aggressive dogs (5) feeding dry food containing
fat among the first 4 ingredients (6) feeding dry food once a day, (5) stress
as an immediate precipitating factor (e.g. travel, kenneling, etc.).
No correlation was found between bloat/torsion and the following: (1) exercise
before or after eating (2) vaccinations (3) dog food brands (4) timing or
volume of water taken before or after eating.
Following his 2003 review of the literature, Dr. Bell concludes: "...we can
list several factors that, added together, can characterize the typical dog
that develops bloat: a deep and narrow chest; leanness; a relative that has
had a bloat episode, eating quickly; a dry-food diet; a single, large daily
meal; stress, and a fearful, nervous, or aggressive temperament."
Researchers look for consistent patterns that predict an outcome greater than
chance. These patterns are not presented as hard-and-fast rules, and
researchers acknowledge that there are exceptions that fall outside of the
patterns.
I hope that this mini-report is useful/interesting to those of you who would
rather not read the studies!!! I am looking for more recent scholarly stuff
(e.g. not from retired vets promoting their supplements). Please share!
Here is the contact info for Dr. Pletcher:
Canine Genomics Initiative
Dr. Mathew Pletcher
The Scripps Research Institute
5353 Parkside Dr.
Jupiter, FL 33458
mpletcher@xxxxxxxxxxx
www.pletcherlab.org
Zoa
Dr. Zoa Rockenstein
www.riverrockshepherds.com
________________________________
From: "TISHW@xxxxxxx" <TISHW@xxxxxxx>
To: fmurch@xxxxxxxxxxxxx; showgsd-l@xxxxxxxxxxxxx
Sent: Monday, January 19, 2009 8:52:26 AM
Subject: [ SHOWGSD-L ] Re: Toxic Gut (long)
In a message dated 1/18/2009 11:25:30 P.M. Eastern Standard Time,
fmurch@xxxxxxxxxxxxx writes:
wish that GSDCA would fund a study through the AKC Health Fund to find out
more about this horrible disease. I never want to lose
another animal to it and I think breeders need to be very honest if this is
occurring in their lines to help save these beautiful animals.
There has to be someone who submits to do a research project on this before
the GSDCA or the Foundation can fund such a study. So far I don't recall any
such research project being submitted to or endorsed by the AKC Health Fund.
Tish
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POST is Copyrighted 2008. All material remains the property of the original
author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind
are permitted without prior permission of the original author AND of the
Showgsd-l Management. ALL RIGHTS RESERVED.
ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY
MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS
PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY
FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE
PROSECUTED.
For assistance, please contact the List Management at admin@xxxxxxxxxxxx
VISIT OUR WEBSITE - http://showgsd.org
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