[ SHOWGSD-L ] Non GSD FW: Momentous news on the Merle Gene, some questions ans...
- From: RihadinK9@xxxxxxx
- To: showgsd-l@xxxxxxxxxxxxx
- Date: Fri, 13 Jan 2006 11:23:50 EST
I know some of you have other breeds. Hope some of find this as newsworthy
as I do!
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Subject: Momentous news on the Merle Gene, some questions answered
Date: Thu, 12 Jan 2006 23:20:47 +0000
> Here's the wonderful news from Keith Murphy's
> laboratory (Canine Genetics Lab) at TAMU (Texas
> A&M University):
> Retrotransposon insertion in SILV is responsible for merle patterning of
> the domestic dog...
> Clark et al. PNAS.2006; 0: 50694010
> _http://www.pnas.org/cgi/reprint/0506940103v1_
> (http://www.pnas.org/cgi/reprint/0506940103v1)
>
> In simple English<G>this means, in a nutshell, that they have
> discovered the merle gene & the specific mutation that causes
> merling, and this is the SAME gene IN ALL DOG BREEDS,
> and a very, very ancient mutation. There will soon be a commercially
> available gene test for merle. This will be useful in many way, not only
> so-called "cryptic" merles (dogs who are merles but don't look it),
> but for telling if our "merles" are heterozygous or homozygous, and
> finding
> out the same answer about many Harlequins, especially those "light
> marked" Harlequins, many of whom are actually "double merles."
>
> So this is momentous. Merling is the only known dog gene definitively
> associated with defects in the dog. This will provide all breeders the
> chance to have more direct and specific information about how to
> breed properly and well. Furthermore the same lab is currently
> pursuing funding ($60,000 is needed) to elucidate the Harlequin
> gene (we have the dogs needed already to complete the study).
>
> It's estimated to take no more than a year's research and this
> *very* reasonable funding, to achieve the same marvelous results
> for Harlequin as have already been achieved in merle. I can only
> hope those who care about Harlequin phenotype will support the
> search for the "other" dominant white gene now that merling has
> been solved by this team!
>
>
=============
Ginger Cleary, Rome, GA
"As nightfall does not come all at once, neither does oppression..."
Justice William O. Douglas, US Supreme Court (1939-75)
_http://www.rihadin.com_ (http://www.rihadin.com/)
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