Have had a rash and what looked like little blisters. I stopped using Frontline every month years ago and used it every 3 months switching off with Advantage or Comfortis. Now, I use a product formulated for trees....yes, trees and shrubs. It is the same ingredient exactly as Advantage but a dilute. Quite safe and does the job...........and a litre bottle is 12.95. Will treat 10-15 dogs every 3 weeks for over a year! Molly In a message dated 6/11/2010 5:42:36 P.M. Central Daylight Time, Tamaringsd@xxxxxxxxxx writes: My Vet shaved the area between Brieanna's shoulder blades, took a picture of the ugly, painful rash and contacted 'Merial', the manufacturer of Frontline Plus and the FDA. Has anyone on this list encountered something like this happening? ============================================================================ POST is Copyrighted 2010. All material remains the property of the original author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any kind are permitted without prior permission of the original author AND of the Showgsd-l Management. ALL RIGHTS RESERVED. ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY MANNER OF ANY MATERIAL WHICH APPEARS ON SHOWGSD-L WITHOUT THE EXPRESS PERMISSION OF ALL PARTIES TO THE POST AND THE LIST MANAGEMENT IS EXPRESSLY FORBIDDEN, AND IS A VIOLATION OF LAW. VIOLATORS OF THIS PROHIBITION WILL BE PROSECUTED. For assistance, please contact the List Management at admin@xxxxxxxxxxx VISIT OUR WEBSITE - http://showgsd.org NATIONAL BLOG - http://gsdnational.blogspot.com/ ============================================================================