[ SHOWGSD-L ] Cyclosporine
- From: "Doc Zoe" <wynsum@xxxxxxx>
- To: showgsd-l@xxxxxxxxxxxxx
- Date: Thu, 19 Jan 2006 23:05:30 -0500
Discovered in soil fungus in 1970, it has tremendously improved graft surv=
ival in all areas of
transplantation. The cyclosporine compound is soluble only in organic solv=
ents or lipids, it is insoluble
in water. It enters the cell passively and binds to cyclophilin causing in=
activation of calcium
dependent activation of the cell. Blocks the signal to lymphocytes to prod=
uce IL-1, IL-2, IL-3, IL-4,
and interferon gamma. Dosage given based on trough (lowest) blood levels. =
Target trough level
depends on the organ transplanted and the time since transplant. Multiple =
different assays are
available for cyclosporine trough levels, actual values will vary dependin=
g on the assay used.
Cyclosporine metabolism is in the liver by the cytochrome p-450 system. Dr=
ugs that induce this
system will decrease the level of cyclosporine, drugs that block this syst=
em will increase cyclosporine
blood levels Side effects include high blood pressure, kidney damage, trem=
ors, headaches, seizures,
excessive hair growth, excessive gum growth, confusion, coma, and gout
Dr Zo=EB M Backman
http://wynsumgsd.com
Support Your Vets and POW/MIAs
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