Although my previous request for information did not receive any responses: //www.freelists.org/archives/rmaexpress_help/08-2007/msg00000.html I now have heard from a second user that they have problems using RMAExpress on Windows Vista. The problem seems to manifest itself during the data input stage. In particular it seems to successfully load the CDF file but fail to read the CEL files. Since I do not currently have a Windows Vista machine I have no ability to debug and test any potential fixes to this problem. Therefore I must sadly announce that RMAExpress on Windows Vista is an unsupported configuration at this time. Note the RMAExpress is still completely functional, and supported, on Windows XP and earlier Windows operating systems. Best, Ben