Interesting conjecture. The vaccine
"Instructing cells to generate the spike protein spurs an immune response,
including generation of antibodies specific to the SARS-CoV-2 spike
protein."
Isn't that what all vaccines do?
On Tue, May 4, 2021 at 12:52 PM Domingo Pichardo <
dmarc-noreply@xxxxxxxxxxxxx> wrote:
This new information is so important right now, yet you will not hear
about it in the MSM and nobody is connecting the dots in how this runs
counter to the Warp Speed "Vaccine" premises of gene therapy by having our
own bodies produce corona spike proteins in order to create antibodies
against them!
https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/
April 30, 2021
The novel coronavirus’ spike protein plays additional key role in illness
Salk researchers and collaborators show how the protein damages cells,
confirming COVID-19 as a primarily vascular disease
LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive
“spike” proteins help the virus infect its host by latching on to healthy
cells. Now, a major new study shows that they also play a key role in the
disease itself.
The paper, published on April 30, 2021, in *Circulation Research*
<https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902>, also
shows conclusively that COVID-19 is a vascular disease, demonstrating
exactly how the SARS-CoV-2 virus damages and attacks the vascular system on
a cellular level. The findings help explain COVID-19’s wide variety of
seemingly unconnected complications, and could open the door for new
research into more effective therapies.
Representative images of vascular endothelial control cells (left) and
cells treated with the SARS-CoV-2 Spike protein (right) show that the spike
protein causes increased mitochondrial fragmentation in vascular cells.
Click here
<https://www.salk.edu/wp-content/uploads/2021/04/manor-figure.png> for a
high-resolution image.
Credit: Salk Institute
“A lot of people think of it as a respiratory disease, but it’s really a
vascular disease,” says Assistant Research Professor Uri Manor
<https://www.salk.edu/scientist/uri-manor/>, who is co-senior author of
the study. “That could explain why some people have strokes, and why some
people have issues in other parts of the body. The commonality between them
is that they all have vascular underpinnings.”
Salk researchers collaborated with scientists at the University of
California San Diego on the paper, including co-first author Jiao Zhang and
co-senior author John Shyy, among others.
While the findings themselves aren’t entirely a surprise, the paper
provides clear confirmation and a detailed explanation of the mechanism
through which the protein damages vascular cells for the first time.
There’s been a growing consensus that SARS-CoV-2 affects the vascular
system, but exactly how it did so was not understood. Similarly, scientists
studying other coronaviruses have long suspected that the spike protein
contributed to damaging vascular endothelial cells, but this is the first
time the process has been documented.
In the new study, the researchers created a “pseudovirus” that was
surrounded by SARS-CoV-2 classic crown of spike proteins, but did not
contain any actual virus. Exposure to this pseudovirus resulted in damage
to the lungs and arteries of an animal model—proving that the spike protein
alone was enough to cause disease. Tissue samples showed inflammation in
endothelial cells lining the pulmonary artery walls.
The team then replicated this process in the lab, exposing healthy
endothelial cells (which line arteries) to the spike protein. They showed
that the spike protein damaged the cells by binding ACE2. This binding
disrupted ACE2’s molecular signaling to mitochondria (organelles that
generate energy for cells), causing the mitochondria to become damaged and
fragmented.
Previous studies have shown a similar effect when cells were exposed to
the SARS-CoV-2 virus, but this is the first study to show that the damage
occurs when cells are exposed to the spike protein on its own.
“If you remove the replicating capabilities of the virus, it still has a
major damaging effect on the vascular cells, simply by virtue of its
ability to bind to this ACE2 receptor, the S protein receptor, now famous
thanks to COVID,” Manor explains. “Further studies with mutant spike
proteins will also provide new insight towards the infectivity and severity
of mutant SARS CoV-2 viruses.”
The researchers next hope to take a closer look at the mechanism by which
the disrupted ACE2 protein damages mitochondria and causes them to change
shape.
Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong
University in Xi’an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald
S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark
Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of
California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and
Shengpeng Wang of Xi’an Jiatong University Health Science Center in Xi’an,
China.
The research was supported by the National Institutes of Health, the
National Natural Science Foundation of China, the Shaanxi Natural Science
Fund, the National Key Research and Development Program, the First
Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong
University.
DOI: 10.1161/CIRCRESAHA.121.318902
A true lover of wisdom has hands too busy to hold on to anything! He
learns by doing and every pebble in the path becomes her teacher! Oink
