Chinese Herb Berberine for Diabetic Health | Berberine Benefits
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Chinese Herb Berberine for Diabetic Health | Berberine Benefits
Chinese Herb Berberine for Diabetic Health | Berberine Benefits Berberine has
very impressive health benefits an...
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https://pubmed.ncbi.nlm.nih.gov/15531889/
Berberine is a novel cholesterol-lowering drug working through a unique
mechanism distinct from statins
Weijia Kong 1, Jing Wei, Parveen Abidi, Meihong Lin, Satoru Inaba, Cong Li,
Yanling Wang, Zizheng Wang, Shuyi Si, Huaining Pan, Shukui Wang, Jingdan Wu,
Yue Wang, Zhuorong Li, Jingwen Liu, Jian-Dong JiangAffiliations expand
- PMID: 15531889
- DOI: 10.1038/nm1135
Abstract
We identify berberine (BBR), a compound isolated from a Chinese herb, as a new
cholesterol-lowering drug. Oral administration of BBR in 32
hypercholesterolemic patients for 3 months reduced serum cholesterol by 29%,
triglycerides by 35% and LDL-cholesterol by 25%. Treatment of hyperlipidemic
hamsters with BBR reduced serum cholesterol by 40% and LDL-cholesterol by 42%,
with a 3.5-fold increase in hepatic LDLR mRNA and a 2.6-fold increase in
hepatic LDLR protein. Using human hepatoma cells, we show that BBR upregulates
LDLR expression independent of sterol regulatory element binding proteins, but
dependent on ERK activation. BBR elevates LDLR expression through a
post-transcriptional mechanism that stabilizes the mRNA. Using a heterologous
system with luciferase as a reporter, we further identify the 5' proximal
section of the LDLR mRNA 3' untranslated region responsible for the regulatory
effect of BBR. These findings show BBR as a new hypolipidemic drug with a
mechanism of action different from that of statin drugs.A true lover of wisdom
has hands too busy to hold on to anything! He learns by doing and every pebble
in the path becomes her teacher! Oink
