http://www.glasgowtr.com/news/cancer-treatment-breakthrough-scientists-discover-diseases-achilles-heel-5912/
A quick note on the specific drug used in the study. It is a new, patented
chemical targeting specifically the CAIX isoenzyme. As such, its long term
safety is unknown and the cost of using it will probably be prohibitive for
most people unless it is prescribed by a doctor. In addition, there is plenty
of evidence that tumors overexpress multiple CA isoenzymes, which means using a
drug selective for just isoenzyme IX is likely to be less therapeutic compared
to a drug that targets most/all of them. One such broad-spectrum CA inhibitor
is acetazolamide, and it is a drug with decades of usage behind its back,
lacking major side effects. So, the available evidence suggests that using
acetazolamide would be preferable to the new, patented drug used in the study
below. Moreover, recent studies have discovered that vitamin B1 (thiamine) is
also a powerful CA inhibitor, on multiple CA isoenzymes, with overall effects
and potency very similar to acetazolamide.
https://pubmed.ncbi.nlm.nih.gov/22145674/
Thus, using thiamine in comparable daily doses (1,000mg-1,500mg) to
acetazolamide should be able to achieve the same effects with even less risk of
side effects. Since thiamine also activaves PDH while also inhibiting PDK,
further cements its potential as a therapy for cancer. As far as the FAO aspect
of cancer metabolism, niacinamide and aspirin are perhaps the best-known and
least risky options to limit both availability (through lipolysis) and
oxidation of lipids by the “cancer” cells. Multiple animal studies have
demonstrated robust anti-cancer effects of niacinamide in HED of
3,000mg-5,000mg daily and aspirin in the same dose range. Since vitamin B1
(thiamine) and niacinamide have synergistic effects, it seems reasonable to
propose vitamin B1+B3 combination (in the dose ranges discussed above) as a
generic/systemic intervention for cancer regardless of its type/location, and
adding aspirin to that combination (even at lower doses than discussed above)
would likely potentiate the anti-cancer effects of the vitamin combination even
more.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323835/
http://cancerimmunolres.aacrjournals.org/content/early/2019/05/14/2326-6066.CIR-18-0657.full-text.pdf
https://www.clinicaltrials.gov/ct2/show/NCT03450018?term=SLC-0111&draw=2&rank=1
http://dx.doi.org/10.1158/1538-7445.AM2021-2015
Cancer treatment breakthrough: Scientists discover disease's 'Achilles' Heel'
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Cancer treatment breakthrough: Scientists discover disease's 'Achilles' ...
Daniel Smith
New findings could hold key to new treatments for the deadliest forms of cancer
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“…Cancer’s ‘Achilles’ Heel’ has been identified by scientists. The protein
fuels tumours when oxygen levels are low, say scientists. It enables them to
adapt and survive – and become more aggressive. The enzyme called CAIX
(Carbonic Anhydrase IX) helps diseased cells spread to other organs. It could
hold the key to new treatments for the deadliest forms including breast,
pancreatic, lungs, bowel and prostate cancers. Study senior author Professor
Shoukat Dedhar, of the University of British Columbia in Canada, said: “Cancer
cells depend on the CAIX enzyme to survive, which ultimately makes it their
‘Achilles’ heel.’ “By inhibiting its activity, we can effectively stop the
cells from growing.”
A true lover of wisdom has hands too busy to hold on to anything! He learns by
doing and every pebble in the path becomes her teacher! Oink
