[optimal] Re: Vegetable Dye
- From: Ethan Priel <prieleye@xxxxxxxxxxxxxxxx>
- To: optimal@xxxxxxxxxxxxx
- Date: Fri, 09 Jul 2010 22:59:39 +0300
Bill.....?
If I didn’t know better I would hazard that you had started on some
glaucoma-preventing medication !
Good call !
Ethan
-----Original Message-----
From: optimal-bounce@xxxxxxxxxxxxx [mailto:optimal-bounce@xxxxxxxxxxxxx] On
Behalf Of William Anderson
Sent: 09 July, 2010 22:51
To: 'optimal@xxxxxxxxxxxxx'
Subject: [optimal] Re: Vegetable Dye
Paula
WHAT, I thought it came from the Fluoreo tree that grows out in West Texas
and in the mountains in Utah. I heard the way it was discovered was when the
Glow Injuns were hunting Jacklopes at night under a blue moon after the
Jacklopes had eaten berries off of the Fluoreo tree all day
Bill
>>> Paula Morris <paula.morris@xxxxxxxxxxxx> 7/9/2010 2:07 PM >>>
Hey Sarah,
The rumor exists because it was stated to be a vegetable dye extracted from
a plant resin first by Duke-Elder, and then by J Federman in the
Intravenous Fluorescein Angiography chapter in Duane's Clinical
Ophthalmology, 1991. That has since been corrected in more recent editions
of Duane's.
Fluorescein's basic component is naphthalene (an extract from the carbolic
acid fraction of coal tar). It is heated with mercury sulfate and copper
sulfate to 400-500 degrees Celsius to become phthallic anhydride. It is
then heated with resorcinol to 200 degrees C. to become resorcinolphthalein,
or fluorescein, which is highly insoluble. When resorcinolphthalein is
dissolved in sodium hydroxide solution, it becomes fluorescein sodium which
is highly soluble and what we use in retinal angiography.
Why do I know this? Because our own Joe Warnicki challenged me back in 1990
to research "Where Does Fluorescein Come From?" That quest led me to
research HJ Conn's biological Stains, the Merck index: An Encyclopedia of
Chemicals, Drugs and Biologicals, Remington's Pharmaceutical Sciences, and
Drug Facts and Comparisons. Fluorescein Sodium is a synthetic dye assigned
by the government to be called F,(food), D (drugs), & C(cosmetics) color
yellow #8. The F,D,C colors are only given to synthetic dyes.
So - it has a vegetable base if you want to harken back to pre-historic
history as plants contributed to the formation of coal deposits, but more
recently I think you could safely say it has a mineral source - naphthalene,
ths tuff that makes moth balls stink. Probably don't want to tell you
patients that...............
And Thus endeth the chemistry lesson!
p
From: optimal-bounce@xxxxxxxxxxxxx [mailto:optimal-bounce@xxxxxxxxxxxxx] On
Behalf Of Sarah Moyer
Sent: Friday, July 09, 2010 10:06 AM
To: optimal@xxxxxxxxxxxxx
Subject: [optimal] Vegetable Dye
July is here and so are the new residents! During a lecture/discussion
about fluorescein sodium yesterday, we discussed how fluorescein sodium is a
synthetic dye and NOT a vegetable dye. One of them had already read/heard
it was a vegetable dye. He asked if there were ever ingredients in the dye
that were vegetable based and if that is why this rumor exists. Does
anybody know why some people refer to it as a vegetable dye?
Thanks!
Sarah Moyer
University of North Carolina
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