. DATABASES: MEDICAL HEALTH BIOSCIENCES BIOLOGY PSYCHOLOGY : BIBLIOGRAPHIES : METAANALYSIS : LITERATURE REVIEWS: Limitations of the MEDLINE Database in Constructing Meta-analyses Limitations of the MEDLINE Database in Constructing Meta-Analyses David E. Winchester, MD; and Anthony A. Bavry, MD, MPH Letter Limitations of the MEDLINE Database in Constructing Meta-Analyses David E. Winchester andAnthony A. Bavry Annals of Internal Medicine September 7, 2010 153:347-348Meta-analyses are important for aggregating trial results to identify conclusions that cannot be made through separate examination. A thorough literature search is of utmost importance in constructing a meta-analysis. The PubMed interface from the National Library of Medicine is a cornerstone of many meta-analysis searches, and the largest component of PubMed is the MEDLINE database. Each article in this database has a unique entry with information about the study's participants and design. However, database entries are available for public search before the entry is finished, leaving a lag time during which data about the study design and participants may not yet be recorded in the database.
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