Hi Felipe, Thank you for the quick reply. I am using MIRA 4.0 on Geneious 8. Do you think it is Geneious error? Also I am trying to assemble Ion Xpress (Ion Torrent) data, if that helps a bit in clarifying the situation. Do you think my mentor's workstation will be able to handle this? Specs: Eight-Core Intel® Xeon® Processor E5-2640 v2 2.00GHz 20MB Cache (95W) (32 Threads total with 16 cores) with 128 GB of RAM BioLinux 8 Thank you again for the fast reply. Kind regards, Zain ________________________________ From: mira_talk-bounce@xxxxxxxxxxxxx <mira_talk-bounce@xxxxxxxxxxxxx> on behalf of Felipe Lira <felipelira3@xxxxxxxxxxxx> Sent: Wednesday, December 17, 2014 8:32 AM To: mira_talk@xxxxxxxxxxxxx Subject: [mira_talk] Re: MIRA Failure - Geneious 8 - Bug report Are you using the newer version of MIRA in Geneious? I had a similar problem but I can use MIRA outside "the box". Felipe Lira Spanish National Center of Biotechnology - CNB/ CSIC Microbial Biotechnology Department Fellow of http://obrasocial.lacaixa.es/ Antes de imprimir este mensaje piense bien si es realmente necesario hacerlo. Before you print this e-mail, think well if it is really necessary. El Miércoles 17 de diciembre de 2014 14:24, Zain A Alvi <zain.alvi@xxxxxxxxxxxxxxx> escribió: Dear Sir or Madam, I hope this reaches you well. I was trying to run MIRA on Geneious 8.0.4 and it crashed. I have attached bug report for your kind review. Please let me know on how to adjust the settings to allow MIRA to work properly on Geneious. I would really appreciate it. Sincerely, Zain