[mira_talk] Re: 32-bit version for mira 3.2.1?
- From: Robin Kramer <kodream@xxxxxxxxx>
- To: mira_talk@xxxxxxxxxxxxx
- Date: Wed, 6 Apr 2011 14:08:04 -0600
Generally I prefer the way they teach in CS, where you implement the
algorithm. IE actually program a dynamic alignment algorithm.
If you can do that then picking up a new alignment algorithm, isn't too
difficult. I find so many people are high centered on a technology because
they only know the switches for that particular black box, so they resist
even keeping up to date on the latest versions of their favorite software.
Sincerely yours,
Robin
On Wed, Apr 6, 2011 at 1:51 PM, John Nash <john.he.nash@xxxxxxxxx> wrote:
> On 2011-04-06, at 3:24 PM, Robin Kramer wrote:
>
> Not quite blast for dummies, but there is a chapter in "Bioinformatics for
> Dummies" on BLAST.
>
>
> http://books.google.com/books?id=4Tw0aZBnBLEC&pg=PA201&lpg=PA201&dq=blast+for+dummies&source=bl&ots=uKqjK6w6wu&sig=Q4SQ7XvjLsILgwC0WmpWFdUJw70&hl=en&ei=wLycTfbmI4r0tgO54_CLBA&sa=X&oi=book_result&ct=result&resnum=4&ved=0CCkQ6AEwAw#v=onepage&q=blast%20for%20dummies&f=false
>
> I love that "The parameters for blast are quite optimal, there is little
> reason to change these, unless of course...".
>
>
> I remember going to my first bioinformatics conference in the early 90s. I
> remember that the first speaker introduced the domain, including some of the
> early tools, e.g. Blast, etc. He said, "If you don't understand what each
> parameter in BLAST means, you should not be using BLAST."
>
> But then, I also remember getting a tape copy of the Staden package in
> FORTRAN, and running it down to the CS department so that they could load it
> on the VAX. I was in grad school then.
>
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