I have just set up a CISCO PIX with a DMZ (ip xxx.xxx.0.101). On the DMZ I have a web server and GFI's Mail Essentials (ME) pre processor. The problem I am currently having is getting ISA to route outbound email to the DMZ ME for outbound filtering. I have setup SMTP filtering on the ISA Server to allow for inbound and outbound traffic. I have also configured the Exchange 2000 SMTP Virtual Server to forward all out going email to the Mail Essentials Server. However, when I do this and send an email out, I receive a ?You do not have permissions to send to specified destination.? If I remove the SMTP forwarder all email is sent out but not filtered. If anyone knows how to correct this problem please help.