Well, I'll have to be biased Columbia-ward with my nominations too, because somehow I haven't made it to very many caches in St. Louis either! FullQuiver did a good job catching the highlights around here, so some of these I'll just second the nomination for.
Best Cache in an Urban Park - The Great Columbian Multicache by a-pineapple (this is actually MANY urban parks, so I don't know if it technically qualifies)
Best Cache in a County Park - Hmm, there are no county parks around here. How about Devils Icebox by scottfamily (state park) or Garden Log by FullQuiver (semi-private park) instead?
Best Puzzle Cache - Cloak & Dagger, Hammer & Sickle by ooga booga
Best Micro - Little Thunder by FullQuiver Best Cache with a View - Lover's Leap by BelieverHardest Cache - Gone Fishin' by A-Pineapple and Spongy_Mesophyll
Most Kid Friendly - Cosmo Family Video Cache! by FullQuiver Most Unusual Cache - Murder by Spongy_Mesophyll
Most Unusual Cache - Little Dixie Buddy Cache by a-pineapple and spongy_mesophyll. Right near I-70, yet so seldom visited.
Most Educational/Historical Cache - Country Church Tour by FullQuiver
Best Area for SLAGA members to do a day cache trip - Columbia (please, we want you to come--we're begging you--we have lots of McToys waiting!!) :)