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Clinical and economic impact of non-adherence in COPD: a systematic review.
Respir Med. 2014 Jan;108(1):103-13
Authors: van Boven JF, Chavannes NH, van der Molen T, Rutten-van Mölken MP,
Postma MJ, Vegter S
Abstract
BACKGROUND: Medication for Chronic Obstructive Pulmonary Disease (COPD) has
shown to substantially reduce symptoms and slow progression of disease.
However, non-adherence to medication is common and associated with worsened
clinical and economic outcomes.
OBJECTIVE: The objective of this study was to perform a systematic review
of published literature to assess the impact of non-adherence to COPD
medication on clinical and economic outcomes.
METHODS: A search in PubMed and Web of Science databases was conducted of
original studies published from database inception to 2012. Studies must
report on the association between adherence to COPD medication and
outcomes, published in English in peer-reviewed journals and full texts
needed to be available.
RESULTS: Twelve full articles were included in the review. Most studies
were retrospective database studies. Seven studies reported on the
association between adherence and clinical outcomes, two on mortality,
three on costs, four on quality of life and one on work productivity.
Results indicated a clear association between adherence and both clinical
and economic outcomes. Evidence from studies revealed increased
hospitalizations, mortality, quality of life and loss of productivity among
non-adherent patients.
CONCLUSION: This review revealed a clear association between non-adherence
to COPD medication and worsened clinical and economic outcomes making
non-adherent patients a priority for cost-effective interventions.
PMID: 24070566 [PubMed - indexed for MEDLINE]
Dette abstract er hentet via PubMed fra National Library of Medicine, USA (
www.ncbi.nlm.nih.gov/home/about/policies).
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