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Dagens #fsvoversigt:
Relation of Smoking With Total Mortality and Cardiovascular Events Among
Patients With Diabetes Mellitus: A Meta-Analysis and Systematic Review.
Circulation. 2015 Nov 10;132(19):1795-804
Authors: Pan A, Wang Y, Talaei M, Hu FB
Abstract
BACKGROUND: The prevalence of smoking in diabetic patients remains high, and
reliable quantification of the excess mortality and morbidity risks associated
with smoking is important for diabetes management. We performed a systematic
review and meta-analysis of prospective cohort studies to evaluate the relation
of active smoking with risk of total mortality and cardiovascular events among
diabetic patients.
METHODS AND RESULTS: We searched Medline and Embase databases through May 2015,
and multivariate-adjusted relative risks were pooled by using random-effects
models. A total of 89 cohort studies were included. The pooled adjusted
relative risk (95% confidence interval) associated with smoking was 1.55
(1.46-1.64) for total mortality (48 studies with 1,132,700 participants and
109,966 deaths), and 1.49 (1.29-1.71) for cardiovascular mortality (13 studies
with 37,550 participants and 3163 deaths). The pooled relative risk (95%
confidence interval) was 1.44 (1.34-1.54) for total cardiovascular disease (16
studies), 1.51 (1.41-1.62) for coronary heart disease (21 studies), 1.54
(1.41-1.69) for stroke (15 studies), 2.15 (1.62-2.85) for peripheral arterial
disease (3 studies), and 1.43 (1.19-1.72) for heart failure (4 studies). In
comparison with never smokers, former smokers were at a moderately elevated
risk of total mortality (1.19; 1.11-1.28), cardiovascular mortality (1.15; 1.0
0-1.32), cardiovascular disease (1.09; 1.05-1.13), and coronary heart disease
(1.14; 1.00-1.30), but not for stroke (1.04; 0.87-1.23).
CONCLUSIONS: Active smoking is associated with significantly increased risks of
total mortality and cardiovascular events among diabetic patients, whereas
smoking cessation is associated with reduced risks in comparison with current
smoking. The findings provide strong evidence for the recommendation of
quitting smoking among diabetic patients.
PMID: 26311724 [PubMed - indexed for MEDLINE]
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Dette abstract er hentet via PubMed fra National Library of Medicine, USA
(http://www.ncbi.nlm.nih.gov/About/disclaimer.html).
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Se abstractet i PubMed: http://evidens.link/1LwDqtL
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