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Dagens #fsvoversigt:
Dose-Response Relationship Between Physical Activity and Risk of Heart Failure:
A Meta-Analysis.
Circulation. 2015 Nov 10;132(19):1786-94
Authors: Pandey A, Garg S, Khunger M, Darden D, Ayers C, Kumbhani DJ, Mayo HG,
de Lemos JA, Berry JD
Abstract
BACKGROUND: Prior studies have reported an inverse association between physical
activity (PA) and risk of heart failure (HF). However, a comprehensive
assessment of the quantitative dose-response association between PA and HF risk
has not been reported previously.
METHODS AND RESULTS: Prospective cohort studies with participants >18 years of
age that reported association of baseline PA levels and incident HF were
included. Categorical dose-response relationships between PA and HF risk were
assessed with random-effects models. Generalized least-squares regression
models were used to assess the quantitative relationship between PA (metabolic
equivalent [MET]-min/wk) and HF risk across studies reporting quantitative PA
estimates. Twelve prospective cohort studies with 20 203 HF events among 370
460 participants (53.5% women; median follow-up, 13 years) were included. The
highest levels of PA were associated with significantly reduced risk of HF
(pooled hazard ratio for highest versus lowest PA, 0.70; 95% confidence
interval, 0.67-0.73). Compared with participants reporting no leisure-time PA,
those who engaged in guideline-recommended minimum levels of PA (500
MET-min/wk; 2008 US federal guidelines) had modest reductions in HF risk (poole
d hazard ratio, 0.90; 95% confidence interval, 0.87-0.92). In contrast, a
substantial risk reduction was observed among individuals who engaged in PA at
twice (hazard ratio for 1000 MET-min/wk, 0.81; 95% confidence interval,
0.77-0.86) and 4 times (hazard ratio for 2000 MET-min/wk, 0.65; 95% confidence
interval, 0.58-0.73) the minimum guideline-recommended levels.
CONCLUSIONS: There is an inverse dose-response relationship between PA and HF
risk. Doses of PA in excess of the guideline-recommended minimum PA levels may
be required for more substantial reductions in HF risk.
PMID: 26438781 [PubMed - indexed for MEDLINE]
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Dette abstract er hentet via PubMed fra National Library of Medicine, USA
(http://www.ncbi.nlm.nih.gov/About/disclaimer.html).
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Se abstractet i PubMed: http://evidens.link/1RrZS3M
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