Advil is an NSAID which is a non steroidal anti inflammatory drug. Of the OTC pain relievers, only Tylenol is not an NSAID. Ibuprofen (Advil & Motrin), naproxen (Aleve) and aspirin are all NSAIDs. NSAIDs relieve pain, reduce fevers and reduce inflammation (like swelling like if you had a sprained ankle). Tylenol is only a pain reliver/fever reducer. It does not have the anti-inflammation properties that NSAIDs have. The benefit Tylenol (acetaminophen) has over NSAIDs is that it is easier on your stomach. Each different drug can also have its own set of drug interactions, so different drugs will be recommended for different things, depending upon its beneficial and adverse effects. Jamie in Michigan Currently Reading - Guarding the Secrets: Palestinian Terrorism and a Father?s Murder of His Too-American Daughter - Ellen Harris