On October 10-11, 2013, the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods and the U.S. Environmental Protection Agency will present a workshop addressing development of new methods to assess and predict whether substances might affect cardiovascular safety in humans. The workshop, titled Translational Alternative Models and Biomarkers Predictive of Drug or Chemical Cardiovascular Risk, will bring together scientists from the pharmaceutical and industrial chemical industries, academia, and regulatory agencies. Workshop participants will consider new approaches to cardiovascular toxicity testing that will provide better safety and risk assessments while reducing or eliminating animal use, how to prioritize research initiatives in this area, and how to bring together data on test substances from various test methods and sources to develop better cardiovascular toxicity hazard assessments. The workshop will include presentations, discussion sessions, and a poster session. More information about the workshop, including links to registration and abstract submission forms, can be found on the NIEHS website at http://tools.niehs.nih.gov/conference/cardiovascular_toxicity/index.cfm.