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June 26 – 27, 2017
NIH Building, 5635 Fishers Lane, Bethesda, MD
Registration: https://ntp.niehs.nih.gov/go/biomed21
Objective: The objective of this workshop is to explore existing systems
biology projects and approaches and how these projects might be better
coordinated to optimally improve disease understanding and interventions.
Summary: Despite investment of billions of dollars over the past few decades,
development of new drugs and other potential disease interventions remains
elusive and immensely expensive. There is a growing recognition that, to
increase the drug development success rate, a stronger focus on human-relevant
data is needed. This data will support implementation of more relevant,
efficient methods to understand chemical toxicity based on understanding and
functionalizing human biological pathways. A number of projects are underway
internationally to mine literature, collect data, and develop these adverse
outcome pathways. This workshop is intended to bring representatives from
several of these projects to a single venue to identify barriers and
opportunities and make recommendations regarding what is needed to achieve the
goal of fully implementing a human systems-biology platform for understanding
disease and improving interventions.
Organizing Committee: Chris Austin (NCATS/NIH), Brian Berridge (GSK), Warren
Casey (NIEHS/NIH), Suzy Fitzpatrick (FDA), Robert Kavlock (EPA), Troy Seidle
(HSI), Anton Simeonov (NCATS/NIH), Dan Tagle (NCATS/NIH), Catherine Willett
(HSUS/HSI)
Organizers: The Human Toxicology Project Consortium and the National Institute
of Environmental Health Sciences
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