[ascct] Webinar on Alt. Approaches to Acute Tox Testing March 5

  • From: Kristie Sullivan <KSullivan@xxxxxxxx>
  • To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
  • Date: Thu, 29 Jan 2015 13:42:12 -0500

The PETA International Science Consortium, Ltd., Physicians Committee for 
Responsible Medicine, NTP Interagency Center for the Evaluation of Alternative 
Toxicological Methods, and Chemical Watch are pleased to invite you to a 
webinar discussion on acute systemic toxicity. This webinar is the fifth in a 
series of six webinars sponsored by the Science Consortium and Chemical Watch 
on alternative test methods for REACH registration, and the first in a series 
of several webinars aimed at discussing various strategies, technologies and 
challenges related to alternative methods for acute systemic toxicity testing 
in a variety of regulatory sectors. This series is part of an effort by 
NICEATM, PCRM, and the Science Consortium to share views and foster discussion 
amongst stakeholders to contribute to an actionable strategy to reduce and 
replace animals for acute systemic toxicity.

Dr. Pilar Prieto will present on EURL ECVAM’s recently released strategy to 
replace, reduce and refine the use of animals in the assessment of acute 
mammalian systemic toxicity. The strategy highlights the importance of 
developing adverse outcome pathways (AOPs) and integrated approaches to testing 
and assessment (IATA) related to acute systemic toxicity. It also discusses 
improvements in the predictability of the 3T3 NRU assay, development of 
additional in vitro and in silico approaches, waiving acute toxicity testing 
based on e.g., repeated dose data, refinement of in vivo studies, and provides 
a framework for prioritizing the alternative methods that have been submitted 
to EURL ECVAM for validation. Following Dr. Prieto’s talk, Dr. Lawrence Milchak 
from 3M will speak to industry experiences on the use of alternative strategies 
to meet acute toxicity testing requirements.

WHO: Pilar Prieto, EURL ECVAM and Lawrence Milchak, 3M
WHAT: Alternative Approaches to Mammalian Acute Systemic Toxicity Testing
WHEN: March 5, 2015, 11 AM - 12 PM US ET
WHERE: Register here: 

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  • » [ascct] Webinar on Alt. Approaches to Acute Tox Testing March 5 - Kristie Sullivan