[ascct] REMINDER: Member webinar April 29: Thyroid Screening and AOPs

  • From: Kristie Sullivan <KSullivan@xxxxxxxx>
  • To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
  • Date: Mon, 29 Apr 2013 11:39:09 -0400



Please join your fellow ASCCT members for a presentation by Katie B. Paul, PhD, 
Oak Ridge Institute for Science and Education (ORISE) Postdoctoral Research 
Fellow at the US Environmental Protection Agency

Using the Adverse Outcome Pathway Framework as a Guide for the Development of 
High-Throughput Screening Assays for Thyroid-Disrupting Chemicals

Disruption of thyroid hormones (THs) adversely affects neurodevelopment in both 
rodent models and humans.  Therefore it is critical to determine the potential 
thyroid-disrupting activity of environmentally-relevant chemicals, but the 
complexity of thyroid hormone regulation necessitates screening assays for 
multiple molecular initiating events that are not currently associated with any 
screening assays. The system of adverse outcome pathways for thyroid 
disruption, the development of a high-throughput screening assay for the 
detection of thyroperoxidase inhibitors, and future thyroid-disruptor screening 
challenges and potential approaches will be discussed.


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Meeting Subject: Member webinar: Thyroid Screening and AOPs
Meeting Date:    Apr 29, 2013
Meeting Time:    2:00 PM EDT
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Kristie Sullivan
Secretary, ASCCT
www.ascctox.org<http://www.ascctox.org>




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