OECD publishes a Guidance Document on the Use of Adverse Outcome Pathways in
developing Integrated Approaches to Testing and Assessment (IATA)
The OECD Programme on Hazard
Assessment<http://www.oecd.org/chemicalsafety/risk-assessment/> addresses the
hazard of chemicals. A current focus of the programme is on the development and
application of Integrated Approaches to Testing and Assessment (IATA) and the
exchange of experience on new hazard assessment methodologies. IATA are
frameworks used for hazard identification, hazard characterisation and/or
safety assessment of a chemical or group of chemicals, which integrate and
weigh all relevant existing data and guide the targeted generation of new data
where required to inform regulatory decision-making regarding a potential
hazard and/or risk.
The objective of this guidance document is to:
• Provide a framework for developing and using integrated approaches
for testing and assessment (IATA),
• Describe how IATA can be based on the Adverse Outcome Pathway (AOP)
• Provide examples on how AOPs can be used in the development of IATA.
For more information on Integrated Approaches to Testing and Assessment, please
to access the publication.
OECD released the e.AOP.Portal, a search engine for AOPs developed in the AOP
Wiki and Effectopedia modules of the AOP-Knowledge Base
The OECD Environmental, Health and Safety (EHS) Programme has been helping
member countries to make better use of increased knowledge of how chemicals
induce adverse effects in humans and wildlife, through the so-called Adverse
OECD launched the e.AOP.Portal<http://aopkb.org/>, the main entry point for the
AOP-Knowledge Base (AOP-KB). It is a search engine that enables search by
keywords in AOP titles and key events in the AOP Wiki<https://aopwiki.org/> and
The e.AOP.Portal main features :
• Informs on the status of AOPs,
• Provides links to published AOPs in OECD
• Allows browsing of AOP external review reports.
For more information on Adverse Outcome Pathways, please consult our
Click here<http://aopkb.org/> to access the e.AOP Portal.