The OECD has just published a guidance document relevant the waiving of
mammalian acute toxicity tests; it can be found here:
Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute
From the Introduction:
The OECD Guidelines for the Testing of Chemicals are continually evolving to
reflect changing assessment practices. Acute toxicity tests are an area of
focus for developing alternative assays to address animal welfare concerns. In
the context of this document, acute toxicity studies refer to studies involving
a single exposure (i.e. a single exposure or multiple exposures within 24
hours) to a test chemical and include those assessing systemic toxicity as well
as those assessing local irritation, corrosion or sensitization. One approach
to minimizing the use of animals for acute toxicity testing is to consider
waiving a study that may be required based on scientific criteria. These
criteria include, but are not limited to, the consideration of physico-chemical
properties of the test chemical or the potential for little or no exposure to
that test chemical by a specific route. Another approach to reducing or
eliminating animal testing is to use existing hazard information that is
informative for the acute toxicity endpoint for the test chemical; this would
include the use of hazard information for one or multiple similar test
chemicals to characterize the hazard for another (often referred to as
read-across) or for mixtures, the use of recognized calculation approaches and
bridging concepts. Clarification of these approaches is important to ensure
that regulatory authorities are provided with the appropriate data required for
decision-making and that reduced animal testing can be undertaken without
compromising the integrity of the hazard information.This email was sent to
members of the American Society for Cellular and Computational Toxicology.
Learn more at www.ascctox.org.
To post, send to ascct@xxxxxxxxxxxxx.
To unsubscribe, send an email with the subject line "unsubscribe" to
To view an archive of list emails, visit www.freelists.org/archive/ascct.