[ascct] OECD encourages the development of non-animal test methods for the detection of thyroid disrupters
- From: Kristie Sullivan <KSullivan@xxxxxxxx>
- To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
- Date: Tue, 21 Oct 2014 13:26:32 -0400
For your information, please see below for a communication from the OECD’s
endocrine advisory group on the need for non-animal test methods for the
detection of thyroid disruptors. It is intended to emphasize the importance of
funding and supporting work to develop and standardize such methods for
regulatory use.
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OECD encourages the development of non-animal test methods for the detection of
thyroid disrupters (click here for online
version<http://www.oecd.org/chemicalsafety/oecd-encourages-development-of-non-animal-test-methods-for-detection-of-thyroid-disrupters.htm>)
The OECD Advisory Group on Endocrine Disrupters Testing and Assessment met on
16-17 October 2014 in Paris to discuss the development and update of Test
Guidelines and related documents for the testing and assessment of endocrine
disrupters. One important endocrine system is the thyroid pathway. Thyroid
hormones are of great importance for the development of Vertebrates. Certain
OECD Test Guidelines on laboratory animals are already addressing toxicity to
the thyroid hormone system, including, for example, the assessment of effects
on brain development.
However, non-animal test methods are also currently needed for more efficient
testing. Progress in developing non-animal tests for the thyroid pathway is
thus a very high priority, in line with the “3-Rs” (Replacement, Reduction,
Refinement) principles. A recent
review<http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO(2014)23&doclanguage=en>
published at the OECD aimed at scoping potential tests. OECD countries are
strongly encouraged to support the development of non-animal tests for the
thyroid pathway that are applicable to the screening and assessment of
endocrine disruption in humans and wildlife.
Proposals to develop standardised OECD Test Guidelines for the detection of
thyroid disrupters should be made via the National
Coordinators<http://www.oecd.org/env/ehs/testing/nationalcoordinatorsofthetestguidelinesprogramme.htm>
of the Test Guidelines Programme.
-----------------------------
See here for more information on:
* OECD work on endocrine
disrupters<http://www.oecd.org/env/ehs/testing/oecdworkrelatedtoendocrinedisrupters.htm>
* OECD efforts on animal
welfare<http://www.oecd.org/env/ehs/testing/animal-welfare.htm>
* OECD work on Test
Guidelines<http://www.oecd.org/env/ehs/testing/oecdguidelinesforthetestingofchemicals.htm>
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