[ascct] Next ASCCT member webinar: TTC
- From: Kristie Sullivan <KSullivan@xxxxxxxx>
- To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
- Date: Tue, 22 Jul 2014 01:12:57 -0400
REMINDER: Next ASCCT webinar this Thursday.
On Jul 8, 2014, at 10:56 AM, Kristie Sullivan
<KSullivan@xxxxxxxx<mailto:KSullivan@xxxxxxxx>> wrote:
Please join us July 24, 2014 at 11:00 US ET for the next ASCCT webinar. In
cooperation with the COSMOS project we will be offering this webinar to the
general public. Registration is not required.
Threshold of Toxicological Concern – an approach for safety assessment and its
applicability to cosmetics-related chemicals
Presenter: Chihae Yang, Altimira, LLC and Molecular Networks
Abstract: In development of alternatives to animal testing, the Threshold
of Toxicological Concern (TTC) approach can serve as one of the practical
safety assessment tools for chemicals for which no in vivo testing results are
available. It is a risk assessment paradigm that establishes a human exposure
threshold value for chemicals, below which there is a low probability of an
appreciable risk to human health.
One of the goals of the COSMOS Project is the evaluation and extension of the
current TTC approach for the safety assessment of cosmetics-related chemicals,
contributing to alternative safety assessment methods urgently needed to
address the repeated toxicity testing of cosmetics. Fundamental to this has
been the compilation of a new oral repeated-dose toxicity database, oRepeatTox
DB, as a resource to construct the new COSMOS non-cancer TTC database of No
Observable Adverse Effect Levels (NOAELs). The TTC database quality was
reviewed by external experts of an ILSI-EU Expert Group. Among the strategies
to address the application of TTC values derived from oral data to use cases
relevant to cosmetics, a tiered decision tree workflow has been elaborated for
the assessment of the chemicals’ bioavailability.
In the webinar, a short general introduction to the TTC concept will be given
and the COSMOS approach to create the new, cosmetics-relevant TTC dataset will
be presented along with the oral-to-dermal extrapolation approach.
Acknowledgements: The COSMOS Project is funded by the European Community’s
Seventh Framework Programme (FP7/2007-2013) under grant agreement number 266835
and the European Cosmetics Association Cosmetics Europe. More information on
the COSMOS Project is available from
http://www.cosmostox.eu<http://www.cosmostox.eu/>.
1. Please join my meeting.
https://global.gotomeeting.com/meeting/join/901631109
2. Use your microphone and speakers (VoIP) - a headset is recommended. Or, call
in using your telephone.
United States: +1 (646) 749-3131
Access Code: 901-631-109
Audio PIN: Shown after joining the meeting
Meeting ID:901-631-109
GoToMeeting
Please contact ASCCT Secretary Kristie Sullivan for more information at
ksullivan@xxxxxxxxxxx<mailto:ksullivan@xxxxxxxxxxx>.
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