[ascct] NTP updates

  • From: Kristie Sullivan <KSullivan@xxxxxxxx>
  • To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
  • Date: Thu, 23 Apr 2015 23:27:23 -0400


ICCVAM will hold a Public Forum on Wednesday, May 27, 2015, from 9:00 a.m. to
12:00 p.m. at the National Institutes of Health Natcher Conference Center in
Bethesda, Maryland. Representatives of the federal agencies on ICCVAM will be
present to hear ideas and suggestions from interested stakeholders and the

The meeting will begin with presentations by NICEATM and ICCVAM members on
current activities related to the development and validation of alternative
test methods and approaches for assessing acute systemic toxicity, endocrine
activity, vaccine safety, and skin sensitization potential, as well as updates
on ICCVAM processes. Following each presentation, there will be an opportunity
for participants to ask questions of the ICCVAM members. The agenda also
includes time for participants to make public oral statements to inform ICCVAM
on topics relevant to its mission and current activities. Attendees are asked
to consider two discussion questions:

1. Do you have suggestions for how best to track progress towards replacement,
reduction, and refinement of animal use for safety testing?
2. Are there specific activities or areas on which you would like to see more
focus from ICCVAM?

Interested persons will be able to attend in person or view the meeting via
webinar. Those wishing to make a public statement are encouraged to attend in
person to facilitate interaction with ICCVAM member agencies. More information
and a link to registration forms are available at
http://ntp.niehs.nih.gov/go/iccvamforum-2015; persons planning to attend are
encouraged to register by May 15.


NTP requests comments on a set of human genes that have been identified and
prioritized as environmentally responsive genes. This set of approximately 1500
"sentinel" genes was developed with input from the scientific community, to be
used in toxicogenomics studies to screen human cells or tissues against large
numbers of chemicals and evaluate transcriptional changes in response to
chemical exposures. The goal is to develop a gene set that (1) is
representative of highly diverse gene expression changes reported to date, (2)
is capable of predicting the gene expression changes observed across the
transcriptome, and (3) covers all major biological pathways.

The current version of the human S1500 gene set can be found at
http://ntp.niehs.nih.gov/go/S1500. This site will be updated as changes to the
list are made. The consensus strategy for selection of an appropriate sentinel
gene set can be accessed at the same site. Comments on the gene set should be
submitted as Microsoft Word or Excel files to
Genelist@xxxxxxxxxxxxx<mailto:Genelist@xxxxxxxxxxxxx> by May 15.

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  • » [ascct] NTP updates - Kristie Sullivan