NIH has issued a Request for Information (RFI): Making Data Usable--A Framework for Community-Based Data and Metadata Standards Efforts for NIH-relevant Research The mission of the NIH Big Data to Knowledge (BD2K) initiative is to enable biomedical scientists to capitalize more fully on the Big Data being generated by those research communities. BD2K aims to develop new approaches, standards, methods, tools, software, and competencies that will enhance the use of biomedical Big Data by supporting research, implementation, and training in data science and other relevant fields. In addressing this goal, an important aspect is to make biomedical research data and resources maximally shareable and reusable. For this reason, BD2K is formulating approaches to encourage development and facilitate the use of data-related (including metadata) standards more broadly across the biomedical research community and is, therefore, interested in the issues involved in developing community-based standards. This RFI solicits comments and ideas related to how community standards activities are initiated, developed, disseminated, and sustained and any role that NIH might play in helping to catalyze such efforts. The deadline for responses it December 5, 2014. Additional information and submitting comments for this RFI are available at http://grants.nih.gov/grants/guide/notice-files/NOT-ES-15-002.html#sthash.b