Dear Colleagues: The NC3Rs public-private partnership "CRACK IT Challenges" for the upcoming year have been announced. There will be a launch and networking event on the 5th of September. The awards are open to non-UK-based applicants but the project leader must be UK-based. Each of the challenges offers up to 1 Million GBP, so if you have collaborators in the UK you may wish to put an application together. Questions can be directed to CRACKITenquiries@xxxxxxxxxxxx<mailto:CRACKITenquiries@xxxxxxxxxxxx>. Kristie Sullivan Secretary, ASCCT www.ascctox.org<http://www.ascctox.org> We are pleased to announce this year’s NC3Rs CRACK IT Challenges 2013 launch event will take place on 5 September in Central London. CRACK IT Challenges is a research competition to solve scientific and business problems identified by the bioscience sector. The Challenges are designed to reduce the reliance on animal models and/or improve animal welfare and lead to the development of marketable products. The competition is run with the SBRI and Challenges are sponsored by companies who provide in-kind contributions such as data, validation and expertise. This year’s competition includes five Challenges, involving seven sponsors: § UnTangle: Development of an iPSC cell neuronal network platform to assay tau spread and pathology for Alzheimer’s Disease drug development. § InPulse: iPSC cardiomyocyte platform to assess drug-induced contractility liabilities. § Inhalation Translation: Development of an approach to non-invasively assess inflammation and adverse events in rodent models of respiratory disease. § NephroTube: Development of a multi-compartmental, microfluidic tissue model of tubular injury in assays of nephrotoxicity. § Virtual Lab: Use of virtual information and tools to enhance disease modelling and new target development. Each of these Challenges offers up to one million GBP funding and a research contract for up to three years. The Challenge briefs will be available on the CRACK IT and SBRI website from 1 August 2013. The launch event is free to attend but registration is essential. You must first register on the CRACK IT website<http://www.crackit.org.uk/calendar/2013launchevent?utm_source=crack+it+email+out&utm_medium=email&utm_campaign=crack+it+2013+launch+email+out> and then for the event itself. Event registration will open at the beginning of August. The programme for the event includes: § Challenge-specific surgeries where participants can meet the sponsors and discuss the Challenges in detail § Networking sessions around Challenge zones providing an opportunity to identify new collaborators to help solve the Challenges § A case study of the CRACK IT Challenges experience from a winner of one of the 2011 CRACK IT Challenges