U.S. Environmental Protection Agency Office of Research and Development National Center for Environmental Research Science to Achieve Results (STAR) Program Organotypic Culture Models for Predictive Toxicology Center Solicitation Opening Date: September 23, 2013 Solicitation Closing Date: January 23, 2014, 11:59:59 pm Eastern Time For more information: http://www.epa.gov/ncer/rfa/2013/2013_star_ocm.html The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications for research centers to investigate toxic effects of chemical substances in three-dimensional (3D) in vitro models, hereafter referred to as ‘organotypic culture models’ (OCMs). OCMs are tissue culture models that mimic in vivotissue architecture through interactions of heterotypic cell types (e.g., epithelium-stroma) and extracellular matrices (ECM). They can be established from isolated cells or from tissue fragments harvested in vivo, and will bridge the gap between conventional monolayer cell cultures and whole-animal systems. Kristie Sullivan Secretary, ASCCT www.ascctox.org<http://www.ascctox.org>