COSMOS: Automated in silico tools for in vitro to in vivo extrapolation
Mon, April 13, 2015
10:00 AM US Eastern Time
Presenter: Alicia Paini, PhD, European Commission Joint Research Centre
EURL ECVAM scientists will provide an opportunity to receive the latest
information on computational tools developed by the COSMOS project
(http://www.cosmostox.eu/) within the Seurat 1 cluster
(http://www.seurat-1.eu/). Among these computational tools, the Virtual Cell
Based Assay (VCBA) and Physiologically Based Kinetic (PBK) models that are
representing the fate and ADME of a chemical in a plastic well-plate and in a
body, respectively. We were able to implement these mathematical models into
KNIME workflows (https://www.knime.org/) to provide automated user-friendly
tools for Scientists and Risk Assessors. These automated tools can be used to
extrapolate from in vitro concentration to in vivo human exposure doses or
viceversa, in order to perform a better risk assessment. These tools are based
solely on in vitro and in silico predictions thus promoting the 3Rs approaches.
https://global.gotomeeting.com/join/738732965
Please join my meeting from your computer, tablet or smartphone.
You can also dial in using your phone.
United States (Long distance): +1 (646) 749-3122
Access Code: 738-732-965
More phone numbers: https://global.gotomeeting.com/738732965/numbersdisplay.html
