[ascct] AOP-related Ancillary meetings at SOT: Please forward widely

  • From: Kristie Sullivan <KSullivan@xxxxxxxx>
  • To: "ascct@xxxxxxxxxxxxx" <ascct@xxxxxxxxxxxxx>
  • Date: Mon, 17 Mar 2014 16:30:44 -0400

Dear Colleagues:

Please consider attending or encouraging your colleagues to attend the 
ancillary/satellite meetings described below and in the attached flier. 
Questions can be directed to me at 
ksullivan@xxxxxxxx<mailto:ksullivan@xxxxxxxx> or 
kwillett@xxxxxxxxxxxxxxxxx<mailto:kwillett@xxxxxxxxxxxxxxxxx>.

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DEVELOPMENT OF A KNOWLEDGE BASE FOR QUANTITATIVE MODELING OF ADVERSE OUTCOME 
PATHWAYS: STAKEHOLDER INPUT SESSIONS

Hyatt Regency Phoenix, 50 E Adams St.

Monday, March 24, 5:00 – 6:30 pm, Borein Room
Tuesday, March 25, 12:00 – 1:30 pm, Cassidy Room
Thursday, March 27, 8:00 – 9:00 am, Remington Room

These three interactive, participatory sessions are intended to elicit 
stakeholder input on the required characteristics of tools currently being 
developed to capture and model quantitative elements of Adverse Outcome 
Pathways in a visual, “wiki” platform. The AOP Knowledge Base will incorporate 
the existing AOP Wiki (aopwiki.org<http://aopwiki.org>) developed by the U.S. 
Environmental Protection Agency and the EC Joint Research Centre along with 
Effectopedia (effectopedia.org), which was originally conceived for this 
purpose by the International QSAR Foundation; its further development and 
integration into the AOP-KB is currently being planned and will be executed in 
2014 and 2015.

Three sessions are offered to increase the participation of stakeholders, and 
all are invited whether from industry, regulatory, academic, or non-profit 
sectors. All levels of experience with AOPs are welcome. Snacks and drinks will 
be served.

_____________________________________________________

AOPs 101: THE HOW AND WHY OF DEVELOPMENT AND USE

Have you heard about pathway-based approaches to toxicology but havent used 
them, are intrigued and wonder if they would work for you?  Or, do you know 
about them and would like to get more invovled in an international effort? This 
is the seminar for you!

March 24, 2014
5:00 - 7:00 PM
Hyatt Regency Phoenix
50 E. Adams St.
Regency Ballroom A

5:00: What are AOPs? Kristie Sullivan, PCRM

5:05: Why are AOPs important, and how can they be useful? Catherine Willett, 
HTPC

5:15: AOPs: Getting Started Terry Schultz, University of Tennessee-Knoxville

·       OECD guidance and template
·       Tools for capturing AOP information
·       Data sources and methods


5:45: Examples from Experience (20 min each)

·       Estrogen receptor-mediated reproductive impairment
Patricia Schmieder, US EPA

·       Development of an AOP for skin sensitization and practical applications
Grace Patlewicz, DuPont

·       Development and use of hepatic AOPs in the SEURAT project cluster
Mathieu Vinken, Free University Brussels

6:45: Additional questions and discussion

Snacks and drinks will be served.

______________________________________________________________

UPDATES ON 21ST CENTURY ACTIVITIES AND RELATED EFFORTS: INVITED PRESENTATIONS 
AND OPEN MICROPHONE

March 27, 2014
12:30-4:00pm
Sheraton Phoenix Downtown Hotel
340 N. 3rd St., Phoenix
Deer Valley Room

For the past several years JHU’s Center for Alternatives to Animal Testing 
(CAAT) has organized satellite meetings in conjunction with the SOT annual 
conferences. The HTPC joined CAAT in co-organizing these meetings beginning in 
2012. The forums have focused on “21st century toxicology” involving in vitro, 
pathway-based approaches, and more recently, have also addressed evidence-based 
toxicology, that is, attempts to translate systematic reviews and related 
approaches from evidence-based medicine into toxicology. The purpose of these 
satellite meetings has been to provide a forum for interested stakeholders to 
update each other on their research and other efforts related to these topics. 
The meetings have been largely informal in the sense that anyone could give a 
presentation, provided that it was germane and brief.

As in 2013, CAAT/HTPC plan to “seed” the 2014 satellite meeting with a limited 
number of invited presentations, but also leave ample time for additional 
presentations and discussion during an “open microphone” segment.


Draft Agenda

12:30
Box lunch and welcome, Thomas Hartung (Johns Hopkins University)

13:00
Invited speakers (10 minute presentations each followed by 5 mins. of 
discussion)

• Alex Merrick* (US National Toxicology Program) – Tox21 Update
• Russell Thomas* (US Environmental Protection Agency) – ToxCast Update
• Melvin Andersen (Hamner Institutes for Biomedical Sciences) – Hamner 
TT21C-related Activity Update
• Michael Schwarz (University of Tuebingen) – SEURAT Update
• Thomas Hartung* (Johns Hopkins University) – The Center for Alternatives to 
Animal Testing’s TT21C-related Activity Update
• Catherine Willett* (Humane Society of the United States) – Human Toxicology 
Project Consortium Update
• Martin Stephens* (Johns Hopkins University) – Evidence-based Toxicology Update

*Confirmed

14:45
Open microphone for additional presentations and discussion

16:00
Adjourn

For more information or to register, please contact Jamie DeRita 
(jderita@xxxxxxxxx<mailto:jderita@xxxxxxxxx>).

Attachment: AOP ancillary meetings flyer (2).pdf
Description: AOP ancillary meetings flyer (2).pdf

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