I'm testing the latest version of Lprof (includes the latest Argyll beta) on OSX with a Spyder2. Though the Spyder is found, I'm getting the error "spyd2: No PLD pattern available!".
As noted right in the top documentation file, next to "Spyder 2": See <http://www.argyllcms.com/doc7/spyd2en.html> As for Lprof, no idea, it's not my project. If they've just blindly copied the code without understanding it, then there could be a few problems (such as saving/finding the firmware file in the right location). Graeme Gill.