I'm going to tag onto Meredith's email, which was awesome. Thank you Meredith.
-for those searching for treatment ideas based in RCTs. -for those who might
not have access to the e-stim machines mentioned earlier in the thread or want
an option for family members / care providers.
Massage
Izgu, N., Metin, Z. G., Karadas, C., Ozdemir, L., Çetin, N., & Demirci, U.
(2019). Prevention of chemotherapy-induced peripheral neuropathy with classical
massage in breast cancer patients receiving paclitaxel: An assessor-blinded
randomized controlled trial. European Journal of Oncology Nursing, 40, 36-43.
Authors documented method of massage.
Menendez, A. G., Cobb, R., Carvajal, A. R., Healey, K., D'Ambra, D., & Espat,
N. J. (2016). Effectiveness of massage therapy (MT) as a treatment strategy and
preventive modality for chemotherapy-induced peripheral neuropathy (CIPN)
symptoms.
Cunningham, J. E., Kelechi, T., Sterba, K., Barthelemy, N., Falkowski, P., &
Chin, S. H. (2011). Case report of a patient with chemotherapy-induced
peripheral neuropathy treated with manual therapy (massage). Supportive Care in
Cancer, 19(9), 1473-1476.
Foot Baths
Park, Ranhee PhD, RN; Park, Chaisoon PhD Comparison of Foot Bathing and Foot
Massage in Chemotherapy-Induced Peripheral Neuropathy, Cancer Nursing: May/June
2015 - Volume 38 - Issue 3 - p 239-247doi: 10.1097/NCC.0000000000000181
(This is a case series out of Korea they did, however, use a device to keep the
temperature of the bath consistent.)
Regards,Earllaine Croarkin, PT, MPTBoard Certified Neurological
SpecialistClinical Research Center, NIH
On Saturday, December 4, 2021, 10:56:28 AM EST, Meredith Wampler-Kuhn
<dmarc-noreply@xxxxxxxxxxxxx> wrote:
I would echo Heidi's comments. We cannot feel confident in the efficacy of
these modalities unless there are good RCTs but to not undersell the power of
placebo effect while waiting. And if you have other modalities that you can
get reimbursed for and that are not an out-of-pocket expense to your patient is
that a better choice?
I would throw it out there that another treatment modality that we do provide
that may provide efficacy for CIPN symptoms is aerobic exercise (which has a
lot of other positive effects on general health, cancer related fatigue, etc.).
Walking is not the best modality for these folks if they have painful
neuropathy or balance problems. But seated bike or recumbent ellipticals like
the NuStep are great options. I will often do this in conjunction with manual
therapy and trigger point release and getting them into orthotics with nice
improvements to functional outcomes like the 6-minute walk test and some
subjective reports of improvement in symptoms.
Here are a few articles (there are more but these could get you started). I
included a few from the diabetic literature because they have more trials than
the CIPN population but may offer some insight as well.
--Meredith1. PMID: 29198853Effects of exercise on cancer patients suffering
chemotherapy-induced peripheral neuropathy undergoing treatment: A systematic
review.Duregon F, Vendramin B, Bullo V, Gobbo S, Cugusi L, Di Blasio A,
Neunhaeuserer D, Zaccaria M, Bergamin M, Ermolao A.Crit Rev Oncol Hematol. 2018
Jan;121:90-100. doi: 10.1016/j.critrevonc.2017.11.002. Epub 2017 Nov 7.PMID:
29198853 Review.
2. PMID: 30462877Aerobic exercise training may improve nerve function in type 2
diabetes and pre-diabetes: A systematic review.Gu Y, Dennis SM, Kiernan MC,
Harmer AR.Diabetes Metab Res Rev. 2019 Feb;35(2):e3099. doi: 10.1002/dmrr.3099.
Epub 2018 Dec 7. PMID: 30462877
3. PMID: 30756229Exercise-based rehabilitation for cancer survivors with
chemotherapy-induced peripheral neuropathy.McCrary JM, Goldstein D, Sandler CX,
Barry BK, Marthick M, Timmins HC, Li T, Horvath L, Grimison P, Park SB.Support
Care Cancer. 2019 Oct;27(10):3849-3857. doi: 10.1007/s00520-019-04680-w. Epub
2019 Feb 12. PMID: 30756229
4. PMID: 31626055Exercise Guidelines for Cancer Survivors: Consensus Statement
from International Multidisciplinary Roundtable.Campbell KL, Winters-Stone KM,
Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel
JA, Gerber LH, Morris GS, Patel AV, Hue TF, Perna FM, Schmitz KH.Med Sci Sports
Exerc. 2019 Nov;51(11):2375-2390. doi: 10.1249/MSS.0000000000002116. PMID:
31626055 Free PMC article.Meredith Wampler-Kuhn, PT, DPTScBoard Certified
Oncologic Physical Therapist
541-706-6335
makuhn@xxxxxxxxxxxxxxxxxxxxxxx
St. Charles Cancer Center
2600 Neff Road
Bend, OR 97701
From: aptaoncology-bounce@xxxxxxxxxxxxx <aptaoncology-bounce@xxxxxxxxxxxxx> on
behalf of heidi engel <dmarc-noreply@xxxxxxxxxxxxx>
Sent: Friday, December 3, 2021 5:25 PM
To: aptaoncology@xxxxxxxxxxxxx <aptaoncology@xxxxxxxxxxxxx>
Subject: [aptaoncology] Re: CIPN treatment -is The Rebuilder electrical
stimulator a viable option from Alane acurry EXTERNAL EMAIL- If suspicious, do
not click on links or open attachments and use Phish Alert to report.
Thanks for asking- when there’s a RCT with the device versus a shame device, we
will have a better answer. The vast majority of devices for pain and sensory
issues and manual therapies are placebo effects. There is Nothing wrong with
that at all. The body heals itself more than we give it credit for in Medicine
(I’m not talking about chemotherapy right?). Placebos are healing, not a system
of tricking the patient. Placebos are legitimate- read some of the sham back
surgery studies for example. Thus, the good news is that we may be able to
achieve a similar result for no money.., that’s my only point here.-Heidi
Sent from my iPhone
On Dec 3, 2021, at 2:33 PM, alane curry <dmarc-noreply@xxxxxxxxxxxxx> wrote:
Deb: the question in the thread is:-Is the Rebuilder an effective treatment
for CIPN?-Potential Journal articles that may support this modality as a viable
treatment.Thanks so much,Alane Curry
Sent from my iPhone
On Dec 3, 2021, at 2:33 PM, Deborah Doherty <doherty@xxxxxxxxxxx> wrote:
HeidiI'm confused. In the email string about the Rebuilder, Perry Ashley
stated: Basically the device is utilized to help refill blood capillaries and
help regain sensation through the legs and feet.However, you are stating it is
a placebo effect. Does this device provide a true physiological effect or a
placebo effect. Or maybe I missed some of the conversation.Thank you for
helping me understand this.Deb
On Fri, Dec 3, 2021 at 10:21 AM heidi engel <dmarc-noreply@xxxxxxxxxxxxx> wrote:
And the greater the patient compliance and attention to the protocol use of the
device, the stronger the placebo effect. Chances are the same sort of
neuropathic distractive effect with placebo could be delivered in a variety of
ways at less expense. Be creative or design a RCT with a placebo device!
-Heidi Engel, PT, DPT
Sent from my iPhone
On Dec 3, 2021, at 6:37 AM, Perry Ashley <dmarc-noreply@xxxxxxxxxxxxx> wrote:
