I'm have a problem with the following Windows 2008 SP2 Enterprise x64 XenApp 5 Enterprise R01 Boxes are Dell blade 8 core + HT 49Gb RAM Local manadatory profiles with full Appsense suite utilising EM + Personalisation service. Desktop / My Documents / Favourites redirected to a Netapp Filer running CIFS. The more users that come onto the box the slower the machine gets. @ 0-45 users the box is responsive, logon times are good but it still has this apparent lag when accessing local apps @ 50 the lag is getting worse sometimes freezes but always comes back. @ 60 logon times are substantial, just selecting a cell in excel can take 30+ seconds. Performance counters seem fine 14% processor time 25k context switches / sec no massive jumps 0 Processor queue length 99% disk idle 0 disk queue length 15-20k threads 0 Redirector\Current Commands The only large one is system calls / sec which can be anywhere from 80k to 1.5m, I've cut down the apps but system calls are still high. To me the server feels as if it has no cpu left, but given the resources free it looks more like an i/o problem, I've tuned the smb with the following [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Lanmanserver\Parameters] "MaxWorkItems"=dword:00002000 "MaxMpxCt"=dword:00000800 (subsequently has been changed to match the Netapp) "MaxRawWorkItems"=dword:00000200 "MaxFreeConnections"=dword:00000064 "MinFreeConnections"=dword:00000020 [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Lanmanworkstation\Parameters] "MaxCmds"=dword:00000800 [HKEY_LOCAL_MACHINE\System\CurrentControlSet\Control\Session Manager\Configuration Manager] "RegistryLazyFlushInterval"=dword:0000003C The NetApp filer has had cifs.max_mpx set to 1124 so I've subsequently changed the citrix servers to match this number rather than the 2048 previously. It's running around 30%cpu 2000 io/sec 98% cache hit. Any suggestions on where else I might look into what is causing the bottleneck? Thanks Andy