[ppi] [ppiindia] Scientists turn immune cells into tumor fighters to treat melanoma

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http://english.pravda.ru/news/science/31-08-2006/84182-melanoma-0

08/31/2006 23:41


      Scientists turn immune cells into tumor fighters to treat melanoma 
     
     

      U.S. government scientists turned regular blood cells into tumor 
attackers that wiped out all signs of cancer in two men with advanced melanoma. 
The striking finding, unveiled Thursday, marks an important step in the quest 
for gene therapy for cancer. 

            
            
                  Gene therapy 
           
            
            
            
            
            
      But the genetically altered cells didn't help 15 other melanoma victims. 
So scientists are trying to strengthen the shots. 

      Still, the National Cancer Institute called its experiment the first real 
success in cancer gene therapy because it fought cancer's worst stage, when it 
has spread through the body, unlike earlier attempts that targeted single 
tumors. 

      And the government hopes to soon begin testing the gene therapy in small 
numbers of patients dying from more common cancers, such as advanced breast or 
colon cancer. 

      The hope is that one day, such treatment might provide long-lasting tumor 
suppression. 

      "It's not like chemotherapy or radiation, where as soon as you're done, 
you're done," said lead researcher Dr. Steven Rosenberg, the NCI's surgery 
chief. "We're giving living cells which continue to grow and function in the 
body." 

      The first two successful patients appear melanoma-free almost two years 
after infusions of tumor fighters made from their own blood. Doctors can't 
predict how the men will fare long-term. Melanoma, the most aggressive skin 
cancer and killer of thousands a year, is notorious for returning years after 
patients think they have subdued it. 

      "I'm cured for now," is how a grateful Mark Origer, 53, put it after a 
checkup from NCI doctors this week. "I know how fortunate I am to have gone 
through this and responded to this. Not everybody's that lucky." 

      Cancer specialists praised the work, published Thursday by the journal 
Science, but warned that years of additional research are needed, reports AP.

      Read 
     


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