Any way to invalidate/flush a single cursor

Does anyone know of a way to invalidate or completely flush a single
cursor?
 
I'm doing some performance testing of queries that are having trouble
with bind variable peeking and sharing plans between executions with
drastically different bind values, so I need to invalidate the cursor in
between executions in order to test the explain plans of different bind
variables.  Is there any more focused approach than gathering stats or
issuing grants on one of the query's tables?  That works, but of course
invalidates all other queries referencing the table.
 
Thanks,
Brandon

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