[net-gold] TOBACCO CIGARETTES CIGARS AND SMOKING: CESSATION QUITING STOPPING : MEDICAL: ISSUES: WEIGHT GAIN: Potential New Target for Smoking Cessation without Weight Gain
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
- To: Net-Gold -- Educator Gold <Educator-Gold@xxxxxxxxxxxxxxx>, Educator Gold <Educator-Gold@xxxxxxxxxxxxxxxx>, net-gold@xxxxxxxxxxxxx, Net-Gold <Net-Gold@xxxxxxxxxxxxxxx>, NetGold <netgold@xxxxxxxxxxxxxxx>, Net-Gold <net-gold@xxxxxxxxxxxxxxxx>, K-12ADMINLIFE <K12ADMIN@xxxxxxxxxxxxxxxxxxx>, K12AdminLIFE <K12AdminLIFE@xxxxxxxxxxxxxxx>, MediaMentor <mediamentor@xxxxxxxxxxxxxxx>, Digital Divide Diversity MLS <mls-digitaldivide@xxxxxxxxxxxxxxx>, NetGold <netgold@xxxxxxxxxxxxxxxx>, Net-Platinum <net-platinum@xxxxxxxxxxxxxxx>, Sean Grigsby <myarchives1@xxxxxxxxxxxxxxx>, Net-Gold <NetGold_general@xxxxxxxxxxxxxxxxx>, Temple Gold Discussion Group <TEMPLE-GOLD@xxxxxxxxxxxxxxxxxxx>, Temple University Net-Gold Archive <net-gold@xxxxxxxxxxxxxxxxxxx>, Health Lists -- Health Diet Fitness Recreation Sports Tourism <healthrecsport@xxxxxxxxxxxxxxxx>, Health Diet Fitness Recreation Sports <healthrecsport@xxxxxxxxxxxxxxx>, HEALTH-RECREATION-SPORTS-TOURISM@xxxxxxxxxxxxxxxxxxx, Sport-Med <SPORT-MED@xxxxxxxxxxxxxx>, sport-med@xxxxxxxxxxxxxxxx, sports-med@xxxxxxxxxxxxxxx, sport-med@xxxxxxxxxxxxxxxxxxx
- Date: Sun, 21 Aug 2011 12:00:10 -0400 (EDT)
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TOBACCO CIGARETTES CIGARS AND SMOKING: CESSATION QUITING STOPPING :
MEDICAL: ISSUES: WEIGHT GAIN:
Potential New Target for Smoking Cessation without Weight Gain
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Date: Thu, 9 Jun 2011 14:52:19 -0400
From: "NIH OLIB (NIH/OD)" <olib@xxxxxxxxxx>
To: NIHPRESS@xxxxxxxxxxxx
Subject: Potential New Target for Smoking Cessation without Weight Gain
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U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
National Institute on Drug Abuse (NIDA)
http://www.nida.nih.gov/
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Embargoed for Release: Thursday, June 9, 2011, 2 p.m. EDT
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CONTACT:
NIDA Press Office
301-443-6245
e-mail:
media@xxxxxxxxxxxx
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POTENTIAL NEW TARGET FOR SMOKING CESSATION WITHOUT WEIGHT GAIN
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NIH-funded study identifies brain pathway in rodents that could be target
of new treatments for smoking and weight control
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A new study uncovers a brain mechanism that could be targeted for new
medications designed to help people quit smoking without gaining weight.
This research, funded by the National Institute on Drug Abuse (NIDA), part
of the National Institutes of Health, shows that a specific subclass of
brain nicotinic receptor is involved in nicotine's ability to reduce food
intake in rodents. Prior research shows that the average weight gain after
smoking is less than 10 pounds, but fear of weight gain can discourage
some people who would like to quit.
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In the study, to be published in the June 10 issue of Science, researchers
found that a nicotine-like drug, cytisine, specifically activated
nicotinic receptors in the hypothalamus - a brain center that controls
feeding. This resulted in the activation of a circuit that reduced food
intake and body fat in a mouse model. This effect was very specific, since
a drug that prevented cytisine from binding to its hypothalamic receptors
blocked the reduction in food intake.
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Through the use of tobacco, nicotine is one of the most heavily used
addictive drugs and the leading preventable cause of disease, disability,
and death in the United States. According to the Centers for Disease
Control and Prevention
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http://www.cdc.gov/chronicdisease/resources/publications/aag/osh.htm
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cigarette smoking results in more than 440,000 preventable deaths each
year - about 1 in 5 U.S. deaths overall. Despite the well-documented
health costs of smoking, many smokers report great difficulty quitting.
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"These mouse models allow us to explore the mechanisms through which
nicotine acts in the brain to reduce food intake," said Dr. Marina
Picciotto, of Yale University, New Haven, Conn. and senior author for the
article. "We found that nicotine reduced eating and body fat through
receptors implicated in nicotine aversion and withdrawal rather than
reward and reinforcement."
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"These results indicate that medications that specifically target this
pathway could alleviate nicotine withdrawal as well as reduce the risk of
overeating during smoking cessation," said NIDA Director Dr. Nora D.
Volkow. "Although more research is warranted, such a highly selective
compound might be more effective than drugs that act on more than one type
of nicotinic receptor."
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For information on tips to maintain a healthy weight while quitting
smoking go to Forever Free: Smoking and Weight
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http://www.smokefree.gov/pubs/FF3.pdf
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a publication of the
National Cancer Institute. For additional information on resources to help
quit smoking, go to
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http://www.nida.nih.gov/DrugPages/Nicotine.html
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and smokefree.gov
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http://www.smokefree.gov/
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The study can be found online at:
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http://www.sciencemag.org/
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About the National Institutes of Health (NIH): NIH, the nation's medical
research agency, includes 27 Institutes and Centers and is a component of
the U.S. Department of Health and Human Services. NIH is the primary
federal agency conducting and supporting basic, clinical, and
translational medical research, and is investigating the causes,
treatments, and cures for both common and rare diseases. For more
information about NIH and its programs, visit
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http://www.nih.gov
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##
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This NIH News Release is available online at:
http://www.nih.gov/news/health/jun2011/nida-09.htm
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Sincerely,
David Dillard
Temple University
(215) 204 - 4584
jwne@xxxxxxxxxx
http://daviddillard.businesscard2.com
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