[net-gold] MEDICAL: DISEASES: PARKINS0N'S DISEASE : PESTICIDES: NIH Study Finds Two Pesticides Associated With Parkinson's Disease
- From: "David P. Dillard" <jwne@xxxxxxxxxx>
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- Date: Sun, 24 Apr 2011 12:20:12 -0400 (EDT)
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MEDICAL: DISEASES: PARKINS0N'S DISEASE :
PESTICIDES:
NIH Study Finds Two Pesticides Associated With Parkinson's Disease
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Date: Fri, 11 Feb 2011 16:14:43 -0500
From: "NIH OLIB (NIH/OD)" <olib@xxxxxxxxxx>
To: NIHPRESS@xxxxxxxxxxxx
Subject: NIH Study Finds Two Pesticides
Associated With Parkinson's Disease
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U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News
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National Institute of Environmental Health Sciences
(NIEHS)
http://www.niehs.nih.gov/
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For Immediate Release: Friday, February 11, 2011
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CONTACT:
Robin Arnette, NIEHS
919-541-5143
e-mail:
arnetter@xxxxxxxxxxxxx
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NIH STUDY FINDS TWO PESTICIDES ASSOCIATED WITH PARKINSON'S DISEASE
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New research shows a link between use of two pesticides, rotenone and
paraquat, and Parkinson's disease. People who used either pesticide
developed Parkinson's disease approximately 2.5 times more often than
non-users.
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The study was a collaborative effort conducted by researchers at the
National Institute of Environmental Health Sciences (NIEHS), which is part
of the National Institutes of Health, and the Parkinson's Institute and
Clinical Center in Sunnyvale, Calif.
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"Rotenone directly inhibits the function of the mitochondria, the
structure responsible for making energy in the cell," said Freya Kamel,
Ph.D., a researcher in the intramural program at NIEHS and co-author of
the paper appearing online in the journal Environmental Health
Perspectives. "Paraquat increases production of certain oxygen derivatives
that may harm cellular structures. People who used these pesticides or
others with a similar mechanism of action were more likely to develop
Parkinson's disease.
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The authors studied 110 people with Parkinson's disease and 358 matched
controls from the Farming and Movement Evaluation (FAME) Study
(http://www.niehs.nih.gov/research/atniehs/labs/epi/studies/fame/index.cfm)
to investigate the relationship between Parkinson's disease and exposure
to pesticides or other agents that are toxic to nervous tissue. FAME is a
case-control study that is part of the larger Agricultural Health Study
(http://www.niehs.nih.gov/research/atniehs/labs/epi/studies/ahs/index.cfm),
a study of farming and health in approximately 90,000 licensed pesticide
applicators and their spouses. The investigators diagnosed Parkinson's
disease by agreement of movement disorder specialists and assessed the
lifelong use of pesticides using detailed interviews.
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There are no home garden or residential uses for either paraquat or
rotenone currently registered. Paraquat use has long been restricted to
certified applicators, largely due to concerns based on studies of animal
models of Parkinson's disease. Use of rotenone as a pesticide to kill
invasive fish species is currently the only allowable use of this
pesticide.
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"These findings help us to understand the biologic changes underlying
Parkinson's disease. This may have important implications for the
treatment and ultimately the prevention of Parkinson's disease," said
Caroline Tanner, M.D., Ph.D., clinical research director of the
Parkinson's Institute and Clinical Center, and lead author of the article.
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The NIEHS supports research to understand the effects of the environment
on human health and is part of NIH. For more information on environmental
health topics, visit <www.niehs.nih.gov>. Subscribe to one or more of the
NIEHS news lists (www.niehs.nih.gov/news/releases/newslist/index.cfm) to
stay current on NIEHS news, press releases, grant opportunities, training,
events, and publications.
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The National Institutes of Health (NIH) -- The Nation's Medical Research
Agency -- includes 27 Institutes and Centers and is a component of the
U.S. Department of Health and Human Services. It is the primary federal
agency for conducting and supporting basic, clinical and translational
medical research, and it investigates the causes, treatments, and cures
for both common and rare diseases. For more information about NIH and its
programs, visit
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http://www.nih.gov
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REFERENCE:
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Tanner CM, Kamel F, Ross GW, Hoppin JA, Goldman SM, Korell M, Marras C,
Bhudhikanok GS, Kasten M, Chade AR, Comyns K, Richards MB, Meng C,
Priestly B, Fernandez HH, Cambi F, Umbach DM, Blair A, Sandler DP,
Langston JW.
2011
Rotenone, paraquat and Parkinson's disease.
Environ Health Perspect
doi:10.1289/ehp.1002839 [Online 26 January 2011].
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##
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This NIH News Release is available online at:
http://www.nih.gov/news/health/feb2011/niehs-11.htm
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Sincerely,
David Dillard
Temple University
(215) 204 - 4584
jwne@xxxxxxxxxx
http://daviddillard.businesscard2.com
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