[lit-ideas] Re: Fw: Andreas's genetics q.

  • From: Carol Kirschenbaum <carolkir@xxxxxxxx>
  • To: lit-ideas@xxxxxxxxxxxxx
  • Date: Thu, 02 Feb 2006 16:18:02 -0800

Aha! Now I have a sense of the difference between human geneticists and fly 
geneticists. My son-the-geneticist addressed Andreas's question as if 
speaking of drosophila. (Oh well. He tried. Good son.)

Thanks for posting, Andreas.

Carol

----- Original Message ----- 
From: "Andreas Ramos" <andreas@xxxxxxxxxxx>
To: <lit-ideas@xxxxxxxxxxxxx>
Sent: Wednesday, February 01, 2006 8:51 PM
Subject: [lit-ideas] Re: Fw: Andreas's genetics q.


> From a list member, sent offlist -- andreas
>
> Genetic mapping is a pretty big term. For numbers on a  particular person, 
> it's the HLA (Human Leukocyte Antigen) map, which looks at a set of 
> molecules (glycoproteins) that are responsible for the way her immune 
> system recognizes 'self' and 'non-self'. Since rejection is a real 
> problem, the idea is to do transplants that the recipient body will think 
> of as 'self' and not have an immune system reaction to. The numbers after 
> the letters are simply designations of which allele (variation) the person 
> has at a particular site on the gene, sort of like saying "blue eyes, 
> brown hair, freckles" only on the chromosome level rather than the 
> exterior, visible one.
> Matching with someone means that you have a lot of the same alleles as 
> they do, thus making it more likely that your bone marrow will grow in 
> their bones without causing them to have an immune reaction. Usually the 
> doctors still give immune-
> suppressing drugs because there are very few perfect matches. As far as 
> the actual numbers, each letter combo ( A, B, C, DRB1) stands for a 
> different locus. The 2 digit number after 'Molecular' part is the 
> serologic equivalent of the antigen. The next 2 digits signify her 
> specific allele. If there is another number following that, it identifies 
> a further subtype.
>
>
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