emule not working

hi folks:
emule & edonkey are programs that are for peer to peer file sharing.they don't 
work behind ISA server 2000,neither firewall client nor NAT client.They use 
4662 for tcp port & 8049 & 4672 for UDP port.I have defined these ports on 
protocol defenitions too but still it doesn't work behind ISA either with NAT 
client without any limitations.
pleaaaaase he;p me as soon as possible.

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